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Adapted Dexamethasone Delivery Polyethylene Oxide and Poly(E-Caprolactone) Construct Promote Mesenchymal Stem Cells Chondrogenesis Publisher Pubmed



Ghiaee A1 ; Pournaqi F1 ; Vakilian S2 ; Mohammadisangcheshmeh A3 ; Ardeshirylajimi A4
Authors
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Authors Affiliations
  1. 1. Department of Biology, Faculty of Science, East Tehran Branch, Islamic Azad University, Tehran, Iran
  2. 2. Stem Cell Technology Research Center, Tehran, Iran
  3. 3. Department of Animal and Poultry Science, College of Aburaihan, University of Tehran, Pakdasht, Iran
  4. 4. Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2017


Abstract

Issues associated with tissue transplantation and shortage of donors has always been a concern, whereas tissue engineering has provided the hopeful opportunities. The aim of this study was to investigate the chondrogenic differentiation potential of mesenchymal stem cells (MSCs) in the presence of embedded Dexamethasone into electrospun Poly(ethyleneoxide) nanofibers composited with Poly(e-caprolactone) nanofibers. Electrospun-fabricated scaffolds were characterized by SEM, tensile, contact angle, release profile, MTT assay, and chonderogenic differentiation of stem cells. Results demonstrated Poly(e-caprolactone) properties improved by composite with a Poly(ethyleneoxide). Overall, stem cells seeded on nanofibers content drug showed highest chondrogenic potential in comparison to the other groups. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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