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Enhanced Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells on Pcl/Plga Electrospun With Different Alignments and Compositions Publisher



Zamanlui S1, 2 ; Mahmoudifard M2, 3 ; Soleimani M2, 4 ; Bakhshandeh B5 ; Vasei M6 ; Faghihi S1
Authors
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Authors Affiliations
  1. 1. Tissue Engineering and Biomaterial Research Center, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  2. 2. Department of Nanotechnology and Tissue Engineering, Stem Cell Technology Research Center, Tehran, Iran
  3. 3. Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran
  4. 4. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  5. 5. Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
  6. 6. Department of Pathology and Digestive Disease, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2018


Abstract

The simultaneous effect of electrospun scaffold alignment and polymer composition on chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBMMSC) is investigated. Aligned and randomly oriented polycaprolactone/poly(lactic-co-glycolic acid) (PLGA) hybrid electrospun scaffolds with two different ratios are fabricated by electrospinning. It is found that aligned nanofibrous scaffolds support higher chondrogenic differentiation of hBMMSCs compared to random ones. The aligned scaffolds show a higher expression level of chondrogenic markers such as type II collagen and aggrecan. It is concluded that the aligned nanofibrous scaffold with higher PLGA ratio could significantly enhance hBMMSC proliferation and differentiation to chondrocytes. © 2018 Taylor & Francis.
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