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White Matter Alterations in Affective and Non-Affective Early Psychosis: A Diffusion Mri Study Publisher Pubmed



Moghaddam HS1 ; Parsaei M2 ; Taghavizanjani F1 ; Cattarinussi G3, 4, 5 ; Aarabi MH3, 4 ; Sambataro F3, 4
Authors
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Authors Affiliations
  1. 1. Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Maternal, Fetal & Neonatal Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Neuroscience (DNS), University of Padova, Padua, Italy
  4. 4. Padova Neuroscience Center, University of Padova, Padua, Italy
  5. 5. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom

Source: Journal of Affective Disorders Published:2024


Abstract

Background: The early years after the onset of psychotic disorders, known as “early psychosis (EP) are critical to determining the path of psychosis trajectory. We used a Diffusion Magnetic Resonance Imaging (DMRI) connectometry approach to assess the microstructural changes of white matter (WM) associated with EP. Methods: We used the Human Connectome Project in Early Psychosis (HCP-EP) dataset to collect DMRI data from patients with EP. The imaging data were processed in the Montreal Neuroimaging Initiative space and transformed into quantitative anisotropy (QA). The QA value was translated into the WM connectivity of each tract and used in the subsequent analysis. Results: 121 patients with EP (94 non-affective/27 affective) and 56 healthy controls were recruited. EP was associated with increased QA in the body and tapetum of corpus callosum (CC) and decreased QA in the bilateral cerebellum, and middle cerebellar peduncle. Compared to non-affective psychosis, affective psychosis showed increased QA in the bilateral cerebellum and vermis and decreased QA in the forceps minor, body of CC, right cingulum, and bilateral inferior fronto-occipital fasciculus. Furthermore, QA changes in several WM tracts were correlated with positive and negative symptom scale scores. Limitations: DMRI intrinsic limitations, limited sample size, and neurobiological effects of psychotropic treatment. Conclusions: EP is associated with alterations in WM connectivity primarily in the CC and cerebellar regions. Also, affective and non-affective psychosis have distinct alterations in WM connectivity. These results can be used for the early diagnosis and differentiation of psychotic disorders. © 2024 The Authors
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