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Effects of Adhd and Adhd Treatment on Glycemic Management in Type 1 Diabetes: A Systematic Review and Meta-Analysis of Observational Studies Publisher Pubmed



Zare Dehnavi A1, 2 ; Elmitwalli I3 ; Alsharif HOH4 ; Shervin Razavi A5 ; Gumpel TA5 ; Smith A6 ; Weinstock RS7, 8 ; Faraone SV9, 10 ; Zhangjames Y9
Authors
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Authors Affiliations
  1. 1. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine & Science, Rochester, 55905, MN, United States
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
  3. 3. Nationwide Children's Hospital, Department of Anesthesiology and Pain Medicine, 700 Children's Drive, Columbus, 43205, OH, United States
  4. 4. Mansoura University Hospital, Dakahlia Governorate, El Mansoura, 7650030, Egypt
  5. 5. Norton College of Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, 13210, NY, United States
  6. 6. Health Sciences Library, Norton College of Medicine at SUNY Upstate Medical University, 750 East Adams Street, Syracuse, 13210, NY, United States
  7. 7. Division of Endocrinology, Diabetes and Metabolism, Norton College of Medicine at SUNY Upstate Medical University, 750 East Adams Street, Syracuse, 13210, NY, United States
  8. 8. Department of Medicine, Norton College of Medicine at SUNY Upstate Medical University, 750 East Adams Street, Syracuse, 13210, NY, United States
  9. 9. Department of Psychiatry & Behavioral Sciences, Norton College of Medicine at SUNY Upstate Medical University, 750 East Adams Street, Syracuse, 13210, NY, United States
  10. 10. Department of Neuroscience and Physiology, Norton College of Medicine at SUNY Upstate Medical University, 750 East Adams Street, Syracuse, 13210, NY, United States

Source: Diabetes Research and Clinical Practice Published:2024


Abstract

Aims: Studies suggested a higher prevalence of Attention-deficit/hyperactivity disorder (ADHD) in individuals with Type 1 Diabetes Mellitus (T1D). However, it is unclear how ADHD impacts glycemia and diabetes-related complications. This systematic review and meta-analysis aimed to investigate the effect of ADHD and ADHD medications on HbA1c and acute complications in T1D. Methods: A literature search was conducted in PubMed, EMBASE, CINAHL, Scopus, PsycINFO, CENTRAL, and Web of Science collections up to November 22, 2023. Seventeen studies were selected for the systematic review by independent reviewers, with twelve included in the meta-analysis. Results: Mean HbA1c levels were significantly higher in T1D individuals with ADHD compared to those without ADHD (MD = 0.60; 95 % CI: 0.41, 0.79; I2 = 90.1 %; p-value < 0.001). The rates of suboptimal HbA1c levels, hospitalization, diabetic ketoacidosis, and hypoglycemia were all substantially higher in T1D individuals with ADHD than those without ADHD. No difference was found in mean HbA1c between those who received ADHD treatment and those who did not (mean difference = -0.52; 95 % confidence interval: −1.16, 0.13; I2 = 78.6 %; p-value = 0.12). Conclusions: ADHD is associated with higher HbA1c and increased acute diabetes-related complications. More research is needed to assess the effects of ADHD treatments on T1D management. © 2024 Elsevier B.V.
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