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The Effects of L-Carnitine Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher



Fathizadeh H1 ; Milajerdi A2, 3 ; Reiner Z4 ; Kolahdooz F5 ; Asemi Z6
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia
  5. 5. Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada
  6. 6. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

Source: EXCLI Journal Published:2019


Abstract

The findings of trials investigating the effect of L-carnitine administration on glycemic control are controversial. This meta-analysis of randomized controlled trials (RCTs) was performed to explore the effects of L-carnitine intake on glycemic control. Two authors independently searched electronic databases including MEDLINE, EM-BASE, Cochrane Library, Web of Science, PubMed and Google scholar from 1990 until February 2019, in order to find relevant RCTs. 37 studies with 44 effect sizes met the inclusion criteria and were eligible for the meta-analysis. L-carnitine supplementation resulted in a significant reduction in fasting plasma glucose (FPG) (WMD:-4.57; 95 % CI:-6.88,-2.25), insulin (WMD:-1.21; 95 % CI:-1.85,-0.57), homeostatic model assessment for insulin resistance (HOMA-IR) (WMD:-0.67; 95 % CI:-0.90,-0.44) and HbA1C concentrations (WMD:-0.30; 95 % CI:-0.47,-0.13). L-Carnitine supplementation significantly reduced FPG, insulin, HOMA-IR, and HbA1c levels. © 2019, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
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