Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Alpha Lipoic Acid on Passive Avoidance and Social Interaction Memory, Pain Perception, and Locomotor Activity in Rem Sleep-Deprived Rats Publisher Pubmed



Mahdavi MS1 ; Nasehi M2 ; Vaseghi S2, 3 ; Mousavi Z1 ; Zarrindast MR3, 4, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  2. 2. Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, P.O. Box: 13145-784, Tehran, Iran
  3. 3. Department of Cognitive Neuroscience, Institute for Cognitive Science Studies (ICSS), Tehran, Iran
  4. 4. Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Neuroendocrinology, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Pharmacological Reports Published:2021


Abstract

Background: Evidence shows the vital role of sleep in the modulation of cognitive functions. Sleep deprivation (SD) can disrupt learning and memory processes. SD also affects pain perception and locomotor activity. Furthermore, alpha lipoic acid (ALA) may induce antioxidant and neuroprotective effects. ALA affects memory processes, pain subthreshold, and locomotor activity. The goal of the present study was to investigate the effect of REM (rapid-eye movement) SD and ALA on social and passive avoidance memory, locomotor activity, and pain perception. Methods: Multiple-platform apparatus was used to induce REM SD for 24 h. Three-chamber paradigm test, the shuttle box, locomotion apparatus, and hot plate were used to assess social interaction memory, passive avoidance memory, locomotor activity, and pain perception, respectively. ALA was injected intraperitoneally at the doses of 35 and 70 mg/kg. Results: 24 h REM SD impaired both types of memory. In addition, ALA (35 mg/kg) reversed REM SD-induced memory impairments. However, ALA (70 mg/kg) impaired social memory with no effect on REM SD-induced memory impairments. ALA (70 mg/kg) also decreased pain subthreshold in REM SD rats. Conclusion: REM SD impairs social interaction and passive avoidance memory. Furthermore, ALA may exhibit a dose-dependent manner in some cognitive tasks. ALA can induce a therapeutic effect at one dose, and an impairment effect at another dose (lower or higher), while the cognitive task and the conditions are equal. © 2020, Maj Institute of Pharmacology Polish Academy of Sciences.
Related Docs
View other Related Docs
1. Modulating Role of Serotonergic Signaling in Sleep and Memory, Pharmacological Reports (2022)
2. The Protective Effect of Alpha Lipoic Acid (Ala) on Social Interaction Memory, But Not Passive Avoidance in Sleep-Deprived Rats, Naunyn-Schmiedeberg's Archives of Pharmacology (2020)
3. The Effect of Fish Oil on Social Interaction Memory in Total Sleep-Deprived Rats With Respect to the Hippocampal Level of Stathmin, Tfeb, Synaptophysin and Lamp-1 Proteins, Prostaglandins Leukotrienes and Essential Fatty Acids (2020)
4. The Interaction Effect of Sleep Deprivation and Cannabinoid Type 1 Receptor in the Ca1 Hippocampal Region on Passive Avoidance Memory, Depressive-Like Behavior and Locomotor Activity in Rats, Behavioural Brain Research (2021)
5. The Role of 5-Ht4 Serotonin Receptors in the Ca1 Hippocampal Region on Memory Acquisition Impairment Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Physiology and Behavior (2020)
6. Do Sleep Disturbances Have a Dual Effect on Alzheimer’S Disease?, Cellular and Molecular Neurobiology (2023)
7. Critical Role of Ca1 Muscarinic Receptors on Memory Acquisition Deficit Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Progress in Neuro-Psychopharmacology and Biological Psychiatry (2017)
8. Chronic Rem Sleep Deprivation Leads to Manic- and Ocd-Related Behaviors, and Decreases Hippocampal Bdnf Expression in Female Rats, Psychopharmacology (2024)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (2)
Maryam Rahmani (1)
Other Related Docs
9. The Effect of Alpha-2 Adrenergic Receptors on Memory Retention Deficit Induced by Rapid Eye Movement Sleep Deprivation, Iranian Journal of Basic Medical Sciences (2020)
10. The Effect of 5-Ht4 Serotonin Receptors in the Ca3 Hippocampal Region on D-Ap5-Induced Anxiolytic-Like Effects: Isobolographic Analyses, Behavioural Brain Research (2021)
11. Activation and Inactivation of Nicotinic Receptnors in the Dorsal Hippocampal Region Restored Negative Effects of Total (Tsd) and Rem Sleep Deprivation (Rsd) on Memory Acquisition, Locomotor Activity and Pain Perception, Neuroscience (2020)
12. Dose-Dependent Manner of Luteolin in the Modulation of Spatial Memory With Respect to the Hippocampal Level of Hsp70 and Hsp90 in Sleep-Deprived Rats, Gene (2023)
13. The Role of Sleep Disturbances in Depressive-Like Behavior With Emphasis on Α-Ketoglutarate Dehydrogenase Activity in Rats., Physiology and Behavior (2020)
14. Cannabinoids and Sleep-Wake Cycle: The Potential Role of Serotonin, Behavioural Brain Research (2021)
15. The Role of Sleep Deprivation in Streptozotocin-Induced Alzheimer’S Disease-Like Sporadic Dementia in Rats With Respect to the Serum Level of Oxidative and Inflammatory Markers, Experimental Brain Research (2022)
16. The Brain-Derived Neurotrophic Factor: Missing Link Between Sleep Deprivation, Insomnia, and Depression, Neurochemical Research (2020)
17. The Effect of Gaba-B Receptors in the Basolateral Amygdala on Passive Avoidance Memory Impairment Induced by Mk-801 in Rats, Behavioural Brain Research (2021)
18. Crocin (Bioactive Compound of Crocus Sativus L.) Potently Restores Rem Sleep Deprivation-Induced Manic- and Obsessive-Compulsive-Like Behaviors in Female Rats, Behavioural Pharmacology (2024)
19. Different Role of Ca1 5Ht3 Serotonin Receptors on Memory Acquisition Deficit Induced Total(Tsd) and Rem Sleep Deprivation(Rsd), Archives of Iranian Medicine (2017)
20. The Effect of Insomnia on Development of Alzheimer's Disease, Journal of Neuroinflammation (2020)
21. Night Shift Hormone: How Does Melatonin Affect Depression?, Physiology and Behavior (2022)
22. Intricate Role of Sleep Deprivation in Modulating Depression: Focusing on Bdnf, Vegf, Serotonin, Cortisol, and Tnf-Α, Metabolic Brain Disease (2023)
23. How Do Stupendous Cannabinoids Modulate Memory Processing Via Affecting Neurotransmitter Systems?, Neuroscience and Biobehavioral Reviews (2021)
24. Investigation of Alpha-Lipoic Acid Effect on Memory Impairment Considering Strain-Dependent Differences in Mice, Life Sciences (2021)
25. The Fluctuations of Metabotropic Glutamate Receptor Subtype 5 (Mglur5) in the Amygdala in Fear Conditioning Model of Male Wistar Rats Following Sleep Deprivation, Reverse Circadian and Napping, Brain Research (2020)
26. The Effect of Ca1 Α2 Adrenergic Receptors on Memory Retention Deficit Induced by Total Sleep Deprivation and the Reversal of Circadian Rhythm in a Rat Model, Neurobiology of Learning and Memory (2016)