Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Role of Sleep Deprivation in Streptozotocin-Induced Alzheimer’S Disease-Like Sporadic Dementia in Rats With Respect to the Serum Level of Oxidative and Inflammatory Markers Publisher Pubmed



Arjmandirad S1 ; Zarrindast MR2 ; Shadfar S3 ; Nasehi M4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Cognitive Neuroscience, Shahid Beheshti University, Tehran, Iran
  2. 2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Centre for Motor Neuron Disease Research, Macquarie Medical School, Macquarie University, Sydney, 2109 NSW, Australia
  4. 4. Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Source: Experimental Brain Research Published:2022


Abstract

Numerous studies have shown the deleterious effects of sleep deprivation (SD) on memory. However, SD in various durations may induce different effects. Studies have reported that short-term or acute SD can improve cognitive functions. In addition, streptozotocin (STZ) significantly impairs learning and memory, and induces inflammation and oxidative stress. In this study, we aimed to investigate the effect of two types of SD (short term: 6 h; long term: 24 h) on STZ-induced spatial memory impairment in rats, with respect to the serum level of catalase (CAT), malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1beta (IL-1β). Morris water maze apparatus was used to assess spatial memory performance and STZ was injected i.c.v., twice, and at the dose of 3 mg/kg, at an interval of 48 h. The results showed that only 24 h SD impaired spatial learning and memory in rats. In addition, 24 h SD attenuated anti-oxidant activity and increased the level of pro-inflammatory markers in the serum. STZ impaired spatial learning and memory, and attenuated anti-oxidant activity and increased the level of pro-inflammatory markers in the serum of rats. Furthermore, 6 h SD slightly and partially improved spatial memory and significantly improved anti-oxidant activity in rats, with no effect on STZ-induced inflammation. We suggest that STZ has more important mechanisms that are involved in its memory impairment effect, and maybe, STZ-induced inflammation has a more important role. We also suggest more detailed studies to investigate the potential therapeutic effect of SD (in different durations) on memory function, oxidative stress, and inflammation. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Related Docs
View other Related Docs
1. Do Sleep Disturbances Have a Dual Effect on Alzheimer’S Disease?, Cellular and Molecular Neurobiology (2023)
2. The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory With Respect to the Oxidative Status of Rats, Neurochemical Research (2023)
3. Dose-Dependent Manner of Luteolin in the Modulation of Spatial Memory With Respect to the Hippocampal Level of Hsp70 and Hsp90 in Sleep-Deprived Rats, Gene (2023)
4. Modulating Role of Serotonergic Signaling in Sleep and Memory, Pharmacological Reports (2022)
5. Intricate Role of Sleep Deprivation in Modulating Depression: Focusing on Bdnf, Vegf, Serotonin, Cortisol, and Tnf-Α, Metabolic Brain Disease (2023)
6. Crocin (Bioactive Compound of Crocus Sativus L.) Potently Restores Rem Sleep Deprivation-Induced Manic- and Obsessive-Compulsive-Like Behaviors in Female Rats, Behavioural Pharmacology (2024)
7. The Interaction Effect of Sleep Deprivation and Cannabinoid Type 1 Receptor in the Ca1 Hippocampal Region on Passive Avoidance Memory, Depressive-Like Behavior and Locomotor Activity in Rats, Behavioural Brain Research (2021)
8. Chronic Rem Sleep Deprivation Leads to Manic- and Ocd-Related Behaviors, and Decreases Hippocampal Bdnf Expression in Female Rats, Psychopharmacology (2024)
Experts (# of related papers)
View all Related Experts
Alireza Imani (3)
Mahdiyeh Faghihi (3)
Other Related Docs
9. Cardioprotective Effects of Acute Sleep Deprivation on Ischemia/Reperfusion Injury, Autonomic Neuroscience: Basic and Clinical (2021)
10. The Effect of Alpha Lipoic Acid on Passive Avoidance and Social Interaction Memory, Pain Perception, and Locomotor Activity in Rem Sleep-Deprived Rats, Pharmacological Reports (2021)
11. Night Shift Hormone: How Does Melatonin Affect Depression?, Physiology and Behavior (2022)
12. The Effect of Insomnia on Development of Alzheimer's Disease, Journal of Neuroinflammation (2020)
13. Acute Sleep Deprivation Preconditions the Heart Against Ischemia/ Reperfusion Injury: The Role of Central Gaba-A Receptors, Iranian Journal of Basic Medical Sciences (2017)
14. The Effect of Fish Oil on Social Interaction Memory in Total Sleep-Deprived Rats With Respect to the Hippocampal Level of Stathmin, Tfeb, Synaptophysin and Lamp-1 Proteins, Prostaglandins Leukotrienes and Essential Fatty Acids (2020)
15. Cannabinoids and Sleep-Wake Cycle: The Potential Role of Serotonin, Behavioural Brain Research (2021)
16. The Protective Effect of Alpha Lipoic Acid (Ala) on Social Interaction Memory, But Not Passive Avoidance in Sleep-Deprived Rats, Naunyn-Schmiedeberg's Archives of Pharmacology (2020)
17. Pre- and Post-Treatment of Α-Tocopherol on Cognitive, Synaptic Plasticity, and Mitochondrial Disorders of the Hippocampus in Icv-Streptozotocin-Induced Sporadic Alzheimer’S-Like Disease in Male Wistar Rat, Frontiers in Neuroscience (2023)
18. The Effect of 5-Ht4 Serotonin Receptors in the Ca3 Hippocampal Region on D-Ap5-Induced Anxiolytic-Like Effects: Isobolographic Analyses, Behavioural Brain Research (2021)
19. How Do Stupendous Cannabinoids Modulate Memory Processing Via Affecting Neurotransmitter Systems?, Neuroscience and Biobehavioral Reviews (2021)
20. The Effect of Gaba-B Receptors in the Basolateral Amygdala on Passive Avoidance Memory Impairment Induced by Mk-801 in Rats, Behavioural Brain Research (2021)
21. The Role of Sleep Disturbances in Depressive-Like Behavior With Emphasis on Α-Ketoglutarate Dehydrogenase Activity in Rats., Physiology and Behavior (2020)
22. Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved, Neurochemical Research (2022)
23. Neurogenesis in the Rat Neonate's Hippocampus With Maternal Short-Term Rem Sleep Deprivation Restores by Royal Jelly Treatment, Brain and Behavior (2021)
24. The Effect of Alpha-2 Adrenergic Receptors on Memory Retention Deficit Induced by Rapid Eye Movement Sleep Deprivation, Iranian Journal of Basic Medical Sciences (2020)
25. Satureja Bachtiarica Ameliorate Beta-Amyloid Induced Memory Impairment, Oxidative Stress and Cholinergic Deficit in Animal Model of Alzheimer’S Disease, Metabolic Brain Disease (2016)
26. Effect of Memantine on Expression of Bace1-As and Bace1 Genes in Stz-Induced Alzheimeric Rats, Molecular Biology Reports (2020)
27. The Correlation of Serum S100β Protein Levels and Hippocampal Seladin-1 Gene Expression in a Rat Model of Sporadic Alzheimer’S Disease, Tehran University Medical Journal (2015)
28. Effect of Memantine on Expression of Nat-Rad18, Rad18 and Sorl1 Genes in Rat Model of Alzheimer's Disease, Journal of Advances in Medical and Biomedical Research (2023)
29. Acute Sleep Deprivation Induces Cardioprotection Against Ischemia/Reperfusion Injury Through Reducing Inflammatory Responses: The Role of Central Gaba-A Receptors, General Physiology and Biophysics (2018)