Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Do Sleep Disturbances Have a Dual Effect on Alzheimer’S Disease? Publisher Pubmed



Arjmandirad S1 ; Ebrahimnejad M2 ; Zarrindast MR3 ; Vaseghi S4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Institute for Cognitive & Brain Sciences, Shahid Beheshti University, Tehran, Iran
  2. 2. Department of Physiology, Faculty of Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, PO Box: 1419815477, Karaj, Iran

Source: Cellular and Molecular Neurobiology Published:2023


Abstract

Sleep disturbances and Alzheimer’s disease have deleterious effects on various physiological and cognitive functions including synaptic plasticity, oxidative stress, neuroinflammation, and memory. In addition, clock genes expression is significantly altered following sleep disturbances, which may be involved in the pathogenesis of Alzheimer’s disease. In this review article, we aimed to discuss the role of sleep disturbances and Alzheimer’s disease in the regulation of synaptic plasticity, oxidative stress, neuroinflammation, and clock genes expression. Also, we aimed to find significant relationships between sleep disturbances and Alzheimer’s disease in the modulation of these mechanisms. We referred to the controversial effects of sleep disturbances (particularly those related to the duration of sleep deprivation) on the modulation of synaptic function and neuroinflammation. We aimed to know that, do sleep disturbances have a dual effect on the progression of Alzheimer's disease? Although numerous studies have discussed the association between sleep disturbances and Alzheimer's disease, the new point of this study was to focus on the controversial effects of sleep disturbances on different biological functions, and to evaluate the potential dualistic role of sleep disturbances in the pathogenesis of Alzheimer's disease. Graphical Abstract: [Figure not available: see fulltext.] © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Related Docs
View other Related Docs
1. Modulating Role of Serotonergic Signaling in Sleep and Memory, Pharmacological Reports (2022)
2. The Role of Sleep Deprivation in Streptozotocin-Induced Alzheimer’S Disease-Like Sporadic Dementia in Rats With Respect to the Serum Level of Oxidative and Inflammatory Markers, Experimental Brain Research (2022)
3. The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory With Respect to the Oxidative Status of Rats, Neurochemical Research (2023)
4. Intricate Role of Sleep Deprivation in Modulating Depression: Focusing on Bdnf, Vegf, Serotonin, Cortisol, and Tnf-Α, Metabolic Brain Disease (2023)
5. Dose-Dependent Manner of Luteolin in the Modulation of Spatial Memory With Respect to the Hippocampal Level of Hsp70 and Hsp90 in Sleep-Deprived Rats, Gene (2023)
6. The Effect of Insomnia on Development of Alzheimer's Disease, Journal of Neuroinflammation (2020)
7. Crocin (Bioactive Compound of Crocus Sativus L.) Potently Restores Rem Sleep Deprivation-Induced Manic- and Obsessive-Compulsive-Like Behaviors in Female Rats, Behavioural Pharmacology (2024)
8. Night Shift Hormone: How Does Melatonin Affect Depression?, Physiology and Behavior (2022)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (6)
Alireza Imani (4)
Other Related Docs
9. The Interaction Effect of Sleep Deprivation and Cannabinoid Type 1 Receptor in the Ca1 Hippocampal Region on Passive Avoidance Memory, Depressive-Like Behavior and Locomotor Activity in Rats, Behavioural Brain Research (2021)
10. Immune Modulations and Immunotherapies for Alzheimer's Disease: A Comprehensive Review, Reviews in the Neurosciences (2022)
11. The Effect of Alpha Lipoic Acid on Passive Avoidance and Social Interaction Memory, Pain Perception, and Locomotor Activity in Rem Sleep-Deprived Rats, Pharmacological Reports (2021)
12. Chronic Rem Sleep Deprivation Leads to Manic- and Ocd-Related Behaviors, and Decreases Hippocampal Bdnf Expression in Female Rats, Psychopharmacology (2024)
13. Cannabinoids and Sleep-Wake Cycle: The Potential Role of Serotonin, Behavioural Brain Research (2021)
14. The Protective Effect of Alpha Lipoic Acid (Ala) on Social Interaction Memory, But Not Passive Avoidance in Sleep-Deprived Rats, Naunyn-Schmiedeberg's Archives of Pharmacology (2020)
15. Neuroinflammation and Proinflammatory Cytokines in Epileptogenesis, Molecular Neurobiology (2022)
16. The Effect of Fish Oil on Social Interaction Memory in Total Sleep-Deprived Rats With Respect to the Hippocampal Level of Stathmin, Tfeb, Synaptophysin and Lamp-1 Proteins, Prostaglandins Leukotrienes and Essential Fatty Acids (2020)
17. Toll-Like Receptors in Alzheimer's Disease, Journal of Neuroimmunology (2020)
18. Critical Role of Ca1 Muscarinic Receptors on Memory Acquisition Deficit Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Progress in Neuro-Psychopharmacology and Biological Psychiatry (2017)
19. Different Protocols of Rem Sleep Deprivation Led to Controversial Effects on Ocd- and Anxiety-Like Behaviors and Locomotor Activity in Fear Conditioning Male and Female Rats With Respect to Bdnf Expression Level, Pharmacology Biochemistry and Behavior (2025)
20. The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases, Molecular Neurobiology (2023)
21. The Effect of Alpha-2 Adrenergic Receptors on Memory Retention Deficit Induced by Rapid Eye Movement Sleep Deprivation, Iranian Journal of Basic Medical Sciences (2020)
22. The Role of 5-Ht4 Serotonin Receptors in the Ca1 Hippocampal Region on Memory Acquisition Impairment Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Physiology and Behavior (2020)
23. The Brain-Derived Neurotrophic Factor: Missing Link Between Sleep Deprivation, Insomnia, and Depression, Neurochemical Research (2020)
24. The Effect of Gaba-B Receptors in the Basolateral Amygdala on Passive Avoidance Memory Impairment Induced by Mk-801 in Rats, Behavioural Brain Research (2021)
25. Activation and Inactivation of Nicotinic Receptnors in the Dorsal Hippocampal Region Restored Negative Effects of Total (Tsd) and Rem Sleep Deprivation (Rsd) on Memory Acquisition, Locomotor Activity and Pain Perception, Neuroscience (2020)
26. Effects of Treadmill Exercise on Social Behavior in Rats Exposed to Thimerosal With Respect to the Hippocampal Level of Glun1, Glun2a, and Glun2b, Journal of Molecular Neuroscience (2022)
27. Benefit Effect of Rem-Sleep Deprivation on Memory Impairment Induced by Intensive Exercise in Male Wistar Rats: With Respect to Hippocampal Bdnf and Trkb, Nature and Science of Sleep (2019)
28. Do Serum Gdnf Levels Correlate With Severity of Alzheimer’S Disease?, Neurological Sciences (2021)
29. Prospects of Saffron and Its Derivatives in Alzheimer's Disease, Archives of Iranian Medicine (2021)
30. Neurogenesis in the Rat Neonate's Hippocampus With Maternal Short-Term Rem Sleep Deprivation Restores by Royal Jelly Treatment, Brain and Behavior (2021)
31. Molecular Anti-Inflammatory Mechanisms of Retinoids and Carotenoids in Alzheimer’S Disease: A Review of Current Evidence, Journal of Molecular Neuroscience (2017)
32. Investigating a Hypothesis on the Mechanism of Long-Term Memory Storage, NeuroQuantology (2019)
33. Effects Silymarin and Rosuvastatin on Amyloid-Carriers Level in Dyslipidemic Alzheimer's Patients: A Double-Blind Placebo-Controlled Randomized Clinical Trial, IBRO Neuroscience Reports (2024)
34. Neurodegenerative Diseases and Brain Delivery of Therapeutics: Bridging the Gap Using Dendrimers, Journal of Drug Delivery Science and Technology (2023)
35. Deferoxamine Regulates Neuroinflammation and Oxidative Stress in Rats With Diabetes-Induced Cognitive Dysfunction, Inflammopharmacology (2020)
36. Exploring the Effect of Gut Microbiome on Alzheimer's Disease, Biochemistry and Biophysics Reports (2024)
37. Stem Cells and Natural Agents in the Management of Neurodegenerative Diseases: A New Approach, Neurochemical Research (2023)
38. Acute Sleep Deprivation Preconditions the Heart Against Ischemia/ Reperfusion Injury: The Role of Central Gaba-A Receptors, Iranian Journal of Basic Medical Sciences (2017)
39. Unfavorable Left Ventricular Remodeling Due to Experience of Chronic Sleep Restriction After Myocardial Infarction: The Role of Matrix Metalloproteinases & Oxidative Stress, Cardiovascular Pathology (2023)
40. The Effect of Ca1 Α2 Adrenergic Receptors on Memory Retention Deficit Induced by Total Sleep Deprivation and the Reversal of Circadian Rhythm in a Rat Model, Neurobiology of Learning and Memory (2016)
41. Cardioprotective Effects of Acute Sleep Deprivation on Ischemia/Reperfusion Injury, Autonomic Neuroscience: Basic and Clinical (2021)
42. Cinnamon, a Promising Prospect Towards Alzheimer's Disease, Pharmacological Research (2018)
43. Complicated Role of Exercise in Modulating Memory: A Discussion of the Mechanisms Involved, Neurochemical Research (2022)