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Nanomedicine for Improvement of Dendritic Cell-Based Cancer Immunotherapy Publisher Pubmed



Hashemi V1, 2 ; Farhadi S3 ; Ghasemi Chaleshtari M4 ; Seashoreludlow B5 ; Masjedi A6 ; Hojjatfarsangi M7, 8 ; Namdar A9 ; Ajjoolabady A4 ; Mohammadi H10 ; Ghalamfarsa G11 ; Jadidiniaragh F12, 13
Authors
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Authors Affiliations
  1. 1. Department of Basic Science, Faculty of Medicine, Maragheh University of Medical Sciences, Maragheh, Iran
  2. 2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden
  6. 6. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Bioclinicum, Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden
  8. 8. The Persian Gulf Marine Biotechnology Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
  9. 9. Department of Oncology, Cross Cancer Institute, The University of Alberta, Edmonton, Alberta, Canada
  10. 10. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  11. 11. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  12. 12. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  13. 13. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Source: International Immunopharmacology Published:2020


Abstract

Dendritic cell (DC)-based cancer immunotherapy has shown impressive outcomes, including the development of the first FDA-approved anti-cancer vaccine. However, the clinical application of DC-based cancer immunotherapy is associated with various challenges. Promising novel tools for the administration of cancer vaccines has emerged from recent developments in nanoscale biomaterials. One current strategy to enhance targeted drug delivery, while minimizing drug-related toxicities, is the use of nanoparticles (NPs). These can be utilized for antigen delivery into DCs, which have been shown to provide potent T cell-stimulating effects. Therefore, NP delivery represents one promising approach for creating an effective and stable immune response without toxic side effects. The current review surveys cancer immunotherapy with particular attention toward NP-based delivery methods that target DCs. © 2020
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