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Emerging Epidemic of Inflammatory Bowel Disease in a Middle Income Country: A Nation-Wide Study From Iran Pubmed



Malekzadeh MM1 ; Vahedi H1 ; Gohari K2, 3 ; Mehdipour P3, 4 ; Sepanlou SG1 ; Daryani NE5 ; Zali MR6 ; Mansourghanaei F7 ; Safarpour AR8 ; Aghazadeh R6 ; Vossoughinia H9 ; Fakheri H10 ; Somi MH11 ; Maleki I10 Show All Authors
Authors
  1. Malekzadeh MM1
  2. Vahedi H1
  3. Gohari K2, 3
  4. Mehdipour P3, 4
  5. Sepanlou SG1
  6. Daryani NE5
  7. Zali MR6
  8. Mansourghanaei F7
  9. Safarpour AR8
  10. Aghazadeh R6
  11. Vossoughinia H9
  12. Fakheri H10
  13. Somi MH11
  14. Maleki I10
  15. Hoseini V10
  16. Ghadir MR12
  17. Daghaghzadeh H13
  18. Adibi P13
  19. Tavakoli H13
  20. Taghavi A8
  21. Zahedi MJ14
  22. Amiriani T15
  23. Tabib M16
  24. Alipour Z16
  25. Nobakht H17
  26. Yazdanbod A18
  27. Sadreddini M19
  28. Bakhshipour A20
  29. Khosravi A9
  30. Khosravi P21
  31. Nasserimoghaddam S1
  32. Merat S1
  33. Sotoudehmanesh R1
  34. Barazandeh F22
  35. Arab P23
  36. Baniasadi N24
  37. Pournaghi SJ21
  38. Parsaeian M3, 25
  39. Farzadfar F3, 4
  40. Malekzadeh R1
Show Affiliations
Authors Affiliations
  1. 1. Digestive Disease Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Gastroenterology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Gastrointestinal and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran
  8. 8. Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9. Department of Gastroenterology and Hepatology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  11. 11. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  12. 12. Department of Gastroenterology, Shahid Be-heshti Hospital, Qom University of Medical Sciences, Qom, Iran
  13. 13. Gastroenterology Section, Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  14. 14. Digestive Research Center, Kerman University of Medical Sciences, Kerman, Iran
  15. 15. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
  16. 16. Department of Internal Medicine, Bushehr University of Medical Science, Bushehr, Iran
  17. 17. Department of Internal Medicine, Semnan University of Medical Science, Semnan, Iran
  18. 18. Department of Medicine, Ardabil University of Medical Science, Ardabil, Iran
  19. 19. Department of Internal Medicine, Urmia University of Medical Sciences, Urmia, Iran
  20. 20. Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  21. 21. Department of Medicine, Dezful University of Medical Science, Dezful, Iran
  22. 22. Department of Internal Medicine, North Khorasan University of Medical Sciences, Bojnourd, North Khorasan, Iran
  23. 23. Department of Gastroenterology and Hepatology, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran
  24. 24. Department of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  25. 25. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Iranian Medicine Published:2016


Abstract

Background: The burden of inflammatory bowel disease (IBD) hasn’t been reported in Iran. We aimed to estimate the prevalence and incidence of IBD and itstrend in Iran at national and subnational level from 1990 to 2012. Methods: We conducted a systematic review of English and Persian databases about the epidemiology of IBD. We also collected outpatient data from 17 provinces of Iran using almost all public and private referral gastroenterology clinics. Prevalence and incidence rate was calculated at national and subnational levels. The Kriging method was used to extrapolate provinces with missing data and GPR model to calculate time trends of rates at subnational level. Results: We found 16 case series, two population-based studies, and two review articles. We collected 11,000 IBD cases from outpatient databases. Among them, 9,269 (84.26%) had ulcerative colitis (UC), 1,646 (14.96%) had Crohn’s disease (CD), and 85 had intermediate colitis (IC). A total of 5,452 (49.56%) patients were male. Mean age at diagnosis was 32.80 years (CI: 13-61) for UC and 29.98 years (CI: 11 -58)forCD. Annual incidences of IBD, UC, and CD in 2012 were 3.11, 2.70, and 0.41 per 100,000 subjects respectively. Prevalence of IBD, UC, and CD in 2012 were 40.67, 35.52, and 5.03 per 100,000 subjects respectively. The incidence of UC and CD showed a significant increase during t he study period (P for trend < 0.05). Conclusions: The incidence and prevalence of IBD are increasing in Iran. Establishing a national IBD registry seems necessary for comprehensive care of IBD patients in Iran. © 2016, National Research and Development Institute for Marine Geology and Geoecology. All rights reserved.
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