The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017

The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017 Publisher Pubmed

Alatab S⁵ ; Sepanlou SG^{5, 8} ; Ikuta K^{11, 12} ; Vahedi H⁵ ; Bisignano C¹² ; Safiri S^{13, 14} ; Sadeghi A⁵ ; Nixon MR¹² ; Abdoli A¹⁶ ; Abolhassani H^{6, 17} ; Alipour V^{19, 20} ; Almadi MAH^{22, 23} ; Almasihashiani A¹⁸ ; Anushiravani A⁴ Show All Authors

Alatab S⁵
Sepanlou SG^{5, 8}
Ikuta K^{11, 12}
Vahedi H⁵
Bisignano C¹²
Safiri S^{13, 14}
Sadeghi A⁵
Nixon MR¹²
Abdoli A¹⁶
Abolhassani H^{6, 17}
Alipour V^{19, 20}
Almadi MAH^{22, 23}
Almasihashiani A¹⁸
Anushiravani A⁴
Arabloo J²¹
Atique S^{24, 25}
Awasthi A^{26, 27}
Badawi A^{28, 29}
Baig AAA^{30, 31}
Bhala N^{32, 33}
Bijani A³⁴
Biondi A³⁵
Borzi AM³⁶
Burke KE³⁷
Carvalho F^{38, 39}
Daryani A⁴⁰
Dubey M⁴¹
Eftekhari A^{15, 43}
Fernandes E⁴⁵
Fernandes JC⁴⁴
Fischer F⁴⁶
Hajmirzaian A^{3, 49}
Hajmirzaian A^{3, 49}
Hasanzadeh A^{2, 42}
Hashemian M^{51, 52}
Hay SI¹²
Hoang CL⁵³
Househ M^{54, 55}
Ilesanmi OS⁵⁶
Balalami NJ⁵⁷
James SL¹²
Kengne AP^{58, 59}
Malekzadeh MM⁵
Merat S⁵
Meretoja TJ^{60, 61}
Mestrovic T^{62, 63}
Mirrakhimov EM^{64, 65}
Mirzaei H^{1, 66}
Mohammad KA^{67, 68}
Mokdad AH^{10, 12}
Monasta L⁶⁹
Negoi I^{70, 71}
Nguyen TH⁵³
Nguyen CT⁷²
Pourshams A⁵
Poustchi H⁵
Rabiee M⁷³
Rabiee N⁷⁴
Ramezanzadeh K⁴⁸
Rawaf DL^{77, 78}
Rawaf S^{75, 79}
Rezaei N^{6, 80}
Robinson SR⁸¹
Ronfani L⁶⁹
Saxena S⁷⁶
Sepehrimanesh M^{82, 83}
Shaikh MA⁸⁴
Sharafi Z⁸⁵
Sharif M^{86, 87}
Siabani S^{88, 89}
Sima AR^{5, 7}
Singh JA⁹⁰
Soheili A^{91, 92}
Sotoudehmanesh R⁵
Suleria HAR⁹³
Tesfay BE⁹⁴
Tran B⁹⁵
Tsoi D¹²
Vacante M³⁵
Wondmieneh AB^{96, 97}
Zarghi A⁴⁷
Zhang ZJ⁹⁸
Dirac M¹²
Malekzadeh R^{5, 9}
Naghavi M^{10, 12}

Source: The Lancet Gastroenterology and Hepatology Published:2020

Abstract

Background: The burden of inflammatory bowel disease (IBD) is rising globally, with substantial variation in levels and trends of disease in different countries and regions. Understanding these geographical differences is crucial for formulating effective strategies for preventing and treating IBD. We report the prevalence, mortality, and overall burden of IBD in 195 countries and territories between 1990 and 2017, based on data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017. Methods: We modelled mortality due to IBD using a standard Cause of Death Ensemble model including data mainly from vital registrations. To estimate the non-fatal burden, we used data presented in primary studies, hospital discharges, and claims data, and used DisMod-MR 2.1, a Bayesian meta-regression tool, to ensure consistency between measures. Mortality, prevalence, years of life lost (YLLs) due to premature death, years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were estimated. All of the estimates were reported as numbers and rates per 100 000 population, with 95% uncertainty intervals (UI). Findings: In 2017, there were 6·8 million (95% UI 6·4–7·3) cases of IBD globally. The age-standardised prevalence rate increased from 79·5 (75·9–83·5) per 100 000 population in 1990 to 84·3 (79·2–89·9) per 100 000 population in 2017. The age-standardised death rate decreased from 0·61 (0·55–0·69) per 100 000 population in 1990 to 0·51 (0·42–0·54) per 100 000 population in 2017. At the GBD regional level, the highest age-standardised prevalence rate in 2017 occurred in high-income North America (422·0 [398·7–446·1] per 100 000) and the lowest age-standardised prevalence rates were observed in the Caribbean (6·7 [6·3–7·2] per 100 000 population). High Socio-demographic Index (SDI) locations had the highest age-standardised prevalence rate, while low SDI regions had the lowest age-standardised prevalence rate. At the national level, the USA had the highest age-standardised prevalence rate (464·5 [438·6–490·9] per 100 000 population), followed by the UK (449·6 [420·6–481·6] per 100 000). Vanuatu had the highest age-standardised death rate in 2017 (1·8 [0·8–3·2] per 100 000 population) and Singapore had the lowest (0·08 [0·06–0·14] per 100 000 population). The total YLDs attributed to IBD almost doubled over the study period, from 0·56 million (0·39–0·77) in 1990 to 1·02 million (0·71–1·38) in 2017. The age-standardised rate of DALYs decreased from 26·5 (21·0–33·0) per 100 000 population in 1990 to 23·2 (19·1–27·8) per 100 000 population in 2017. Interpretation: The prevalence of IBD increased substantially in many regions from 1990 to 2017, which might pose a substantial social and economic burden on governments and health systems in the coming years. Our findings can be useful for policy makers developing strategies to tackle IBD, including the education of specialised personnel to address the burden of this complex disease. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

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Style	Citing Format
MLA	Alatab S, et al.. "The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017." The Lancet Gastroenterology and Hepatology, vol. 5, no. 1, 2020, pp. 17-30.
APA	Alatab S, Sepanlou SG, Ikuta K, Vahedi H, Bisignano C, Safiri S, Sadeghi A, Nixon MR, Abdoli A, Abolhassani H, Alipour V, Almadi MAH, Almasihashiani A, Anushiravani A, Arabloo J, Atique S, Awasthi A, Badawi A, Baig AAA, ... Naghavi M (2020). The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017. The Lancet Gastroenterology and Hepatology, 5(1), 17-30.
Chicago	Alatab S, Sepanlou SG, Ikuta K, Vahedi H, Bisignano C, Safiri S, Sadeghi A, et al.. "The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017." The Lancet Gastroenterology and Hepatology 5, no. 1 (2020): 17-30.
Harvard	Alatab S et al. (2020) 'The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017', The Lancet Gastroenterology and Hepatology, 5(1), pp. 17-30.
Vancouver	Alatab S, Sepanlou SG, Ikuta K, Vahedi H, Bisignano C, Safiri S, et al.. The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017. The Lancet Gastroenterology and Hepatology. 2020;5(1):17-30.
BibTex	@article{ author = {Alatab S and Sepanlou SG and Ikuta K and Vahedi H and Bisignano C and Safiri S and Sadeghi A and Nixon MR and Abdoli A and Abolhassani H and Alipour V and Almadi MAH and Almasihashiani A and Anushiravani A and Arabloo J and Atique S and Awasthi A and Badawi A and Baig AAA and Bhala N and Bijani A and Biondi A and Borzi AM and Burke KE and Carvalho F and Daryani A and Dubey M and Eftekhari A and Fernandes E and Fernandes JC and Fischer F and Hajmirzaian A and Hajmirzaian A and Hasanzadeh A and Hashemian M and Hay SI and Hoang CL and Househ M and Ilesanmi OS and Balalami NJ and James SL and Kengne AP and Malekzadeh MM and Merat S and Meretoja TJ and Mestrovic T and Mirrakhimov EM and Mirzaei H and Mohammad KA and Mokdad AH and Monasta L and Negoi I and Nguyen TH and Nguyen CT and Pourshams A and Poustchi H and Rabiee M and Rabiee N and Ramezanzadeh K and Rawaf DL and Rawaf S and Rezaei N and Robinson SR and Ronfani L and Saxena S and Sepehrimanesh M and Shaikh MA and Sharafi Z and Sharif M and Siabani S and Sima AR and Singh JA and Soheili A and Sotoudehmanesh R and Suleria HAR and Tesfay BE and Tran B and Tsoi D and Vacante M and Wondmieneh AB and Zarghi A and Zhang ZJ and Dirac M and Malekzadeh R and Naghavi M}, title = {The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017}, journal = {The Lancet Gastroenterology and Hepatology}, volume = {5}, number = {1}, pages = {17-30}, year = {2020} }
RIS	TY - JOUR AU - Alatab S AU - Sepanlou SG AU - Ikuta K AU - Vahedi H AU - Bisignano C AU - Safiri S AU - Sadeghi A AU - Nixon MR AU - Abdoli A AU - Abolhassani H AU - Alipour V AU - Almadi MAH AU - Almasihashiani A AU - Anushiravani A AU - Arabloo J AU - Atique S AU - Awasthi A AU - Badawi A AU - Baig AAA AU - Bhala N AU - Bijani A AU - Biondi A AU - Borzi AM AU - Burke KE AU - Carvalho F AU - Daryani A AU - Dubey M AU - Eftekhari A AU - Fernandes E AU - Fernandes JC AU - Fischer F AU - Hajmirzaian A AU - Hajmirzaian A AU - Hasanzadeh A AU - Hashemian M AU - Hay SI AU - Hoang CL AU - Househ M AU - Ilesanmi OS AU - Balalami NJ AU - James SL AU - Kengne AP AU - Malekzadeh MM AU - Merat S AU - Meretoja TJ AU - Mestrovic T AU - Mirrakhimov EM AU - Mirzaei H AU - Mohammad KA AU - Mokdad AH AU - Monasta L AU - Negoi I AU - Nguyen TH AU - Nguyen CT AU - Pourshams A AU - Poustchi H AU - Rabiee M AU - Rabiee N AU - Ramezanzadeh K AU - Rawaf DL AU - Rawaf S AU - Rezaei N AU - Robinson SR AU - Ronfani L AU - Saxena S AU - Sepehrimanesh M AU - Shaikh MA AU - Sharafi Z AU - Sharif M AU - Siabani S AU - Sima AR AU - Singh JA AU - Soheili A AU - Sotoudehmanesh R AU - Suleria HAR AU - Tesfay BE AU - Tran B AU - Tsoi D AU - Vacante M AU - Wondmieneh AB AU - Zarghi A AU - Zhang ZJ AU - Dirac M AU - Malekzadeh R AU - Naghavi M TI - The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017 JO - The Lancet Gastroenterology and Hepatology VL - 5 IS - 1 SP - 17 EP - 30 PY - 2020 ER -

Style

Citing Format

MLA

Alatab S, et al.. "The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017." The Lancet Gastroenterology and Hepatology, vol. 5, no. 1, 2020, pp. 17-30.

APA

Alatab S, Sepanlou SG, Ikuta K, Vahedi H, Bisignano C, Safiri S, Sadeghi A, Nixon MR, Abdoli A, Abolhassani H, Alipour V, Almadi MAH, Almasihashiani A, Anushiravani A, Arabloo J, Atique S, Awasthi A, Badawi A, Baig AAA, ... Naghavi M (2020). The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017. The Lancet Gastroenterology and Hepatology, 5(1), 17-30.

Chicago

Alatab S, Sepanlou SG, Ikuta K, Vahedi H, Bisignano C, Safiri S, Sadeghi A, et al.. "The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017." The Lancet Gastroenterology and Hepatology 5, no. 1 (2020): 17-30.

Harvard

Alatab S et al. (2020) 'The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017', The Lancet Gastroenterology and Hepatology, 5(1), pp. 17-30.

Vancouver

Alatab S, Sepanlou SG, Ikuta K, Vahedi H, Bisignano C, Safiri S, et al.. The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017. The Lancet Gastroenterology and Hepatology. 2020;5(1):17-30.

BibTex

@article{ author = {Alatab S and Sepanlou SG and Ikuta K and Vahedi H and Bisignano C and Safiri S and Sadeghi A and Nixon MR and Abdoli A and Abolhassani H and Alipour V and Almadi MAH and Almasihashiani A and Anushiravani A and Arabloo J and Atique S and Awasthi A and Badawi A and Baig AAA and Bhala N and Bijani A and Biondi A and Borzi AM and Burke KE and Carvalho F and Daryani A and Dubey M and Eftekhari A and Fernandes E and Fernandes JC and Fischer F and Hajmirzaian A and Hajmirzaian A and Hasanzadeh A and Hashemian M and Hay SI and Hoang CL and Househ M and Ilesanmi OS and Balalami NJ and James SL and Kengne AP and Malekzadeh MM and Merat S and Meretoja TJ and Mestrovic T and Mirrakhimov EM and Mirzaei H and Mohammad KA and Mokdad AH and Monasta L and Negoi I and Nguyen TH and Nguyen CT and Pourshams A and Poustchi H and Rabiee M and Rabiee N and Ramezanzadeh K and Rawaf DL and Rawaf S and Rezaei N and Robinson SR and Ronfani L and Saxena S and Sepehrimanesh M and Shaikh MA and Sharafi Z and Sharif M and Siabani S and Sima AR and Singh JA and Soheili A and Sotoudehmanesh R and Suleria HAR and Tesfay BE and Tran B and Tsoi D and Vacante M and Wondmieneh AB and Zarghi A and Zhang ZJ and Dirac M and Malekzadeh R and Naghavi M}, title = {The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017}, journal = {The Lancet Gastroenterology and Hepatology}, volume = {5}, number = {1}, pages = {17-30}, year = {2020} }

RIS

TY - JOUR
AU - Alatab S
AU - Sepanlou SG
AU - Ikuta K
AU - Vahedi H
AU - Bisignano C
AU - Safiri S
AU - Sadeghi A
AU - Nixon MR
AU - Abdoli A
AU - Abolhassani H
AU - Alipour V
AU - Almadi MAH
AU - Almasihashiani A
AU - Anushiravani A
AU - Arabloo J
AU - Atique S
AU - Awasthi A
AU - Badawi A
AU - Baig AAA
AU - Bhala N
AU - Bijani A
AU - Biondi A
AU - Borzi AM
AU - Burke KE
AU - Carvalho F
AU - Daryani A
AU - Dubey M
AU - Eftekhari A
AU - Fernandes E
AU - Fernandes JC
AU - Fischer F
AU - Hajmirzaian A
AU - Hajmirzaian A
AU - Hasanzadeh A
AU - Hashemian M
AU - Hay SI
AU - Hoang CL
AU - Househ M
AU - Ilesanmi OS
AU - Balalami NJ
AU - James SL
AU - Kengne AP
AU - Malekzadeh MM
AU - Merat S
AU - Meretoja TJ
AU - Mestrovic T
AU - Mirrakhimov EM
AU - Mirzaei H
AU - Mohammad KA
AU - Mokdad AH
AU - Monasta L
AU - Negoi I
AU - Nguyen TH
AU - Nguyen CT
AU - Pourshams A
AU - Poustchi H
AU - Rabiee M
AU - Rabiee N
AU - Ramezanzadeh K
AU - Rawaf DL
AU - Rawaf S
AU - Rezaei N
AU - Robinson SR
AU - Ronfani L
AU - Saxena S
AU - Sepehrimanesh M
AU - Shaikh MA
AU - Sharafi Z
AU - Sharif M
AU - Siabani S
AU - Sima AR
AU - Singh JA
AU - Soheili A
AU - Sotoudehmanesh R
AU - Suleria HAR
AU - Tesfay BE
AU - Tran B
AU - Tsoi D
AU - Vacante M
AU - Wondmieneh AB
AU - Zarghi A
AU - Zhang ZJ
AU - Dirac M
AU - Malekzadeh R
AU - Naghavi M
TI - The Global, Regional, and National Burden of Inflammatory Bowel Disease in 195 Countries and Territories, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017
JO - The Lancet Gastroenterology and Hepatology
VL - 5
IS - 1
SP - 17
EP - 30
PY - 2020
ER -

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