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Profiling Inflammatory Mechanisms, Hyperphosphorylated Tau of Hippocampal Tissue and Spatial Memory Following Vitamin D3 Treatment in the Mice Model of Vascular Dementia Publisher Pubmed



Sadeghzadeh J1 ; Jafarzadeh J2, 3 ; Hadinezhad P4, 5 ; Nazari A6 ; Sohrabi S7 ; Musazadeh V2, 8 ; Barzegar A3 ; Shahabi P9, 10
Authors
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Authors Affiliations
  1. 1. Department of Neuroscience and Cognition, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Community Nutrition, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Psychiatry, Mazandaran University of Medical Sciences, Sari, Iran
  5. 5. Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Tehran University of Medical Sciences, Tehran, Iran
  7. 7. School of Medicine, Babol University of Medical Sciences, Babol, Iran
  8. 8. School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Departments of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Source: International Immunopharmacology Published:2023


Abstract

Background: The aim of this study was to investigate the effect of vitamin D3 (VitD3) on inflammatory mechanisms, hyperphosphorylated tau (p-tau) in the hippocampus, and cognitive impairment of the mouse model of vascular dementia (VaD). Methods: In this study, 32 male mice were randomly assigned to the control, VaD, VitD3 (300 IU/Kg/day), and VitD3 (500 IU/Kg/day) groups. VaD and VitD3 groups were gavaged daily for 4 weeks with a gastric needle. For biochemical assessments, blood samples and the hippocampus were isolated. IL-1β and TNF-α were analyzed by ELISA, and p-tau and other inflammatory molecules were measured by western blot. Results: VitD3 supplements significantly (P < 0.05) decreased the level of inflammatory factors in the hippocampus and prevented apoptosis. However, regarding p-tau in hippocampal tissue, this decrease was not statistically significant (P > 0.05). The results of behavioral assessments showed that VitD3 significantly improved the spatial memory of treated mice. Conclusion: These results suggest that the neuroprotective effects of VitD3 are mainly associated with their anti-inflammatory effects. © 2023 Elsevier B.V.
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