A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer

A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer Publisher

Mehrizi TZ¹ ; Mosaffa N² ; Khamesipour A³ ; Hoseini MHM² ; Shahmabadi HE⁴ ; Ardestani MS⁵ ; Ramezani A¹

Show Affiliations

1. Department of Clinical Research, Pasteur Institute of Iran, Tehran, Iran
2. Department of Medical Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Microbiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
5. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Nanostructures Published:2021

Abstract

Betulinic acid (BA) is an antileishmanial herbal drug with low solubility and high toxicity. To our knowledge, this is the first study in which betulinic acid is loaded into Anionic Linear Globular Dendrimer (ALGD) in order to resolve the toxicity and insolubility problem. In order to solve mentioned problems, BA was loaded into ALGD nanocarrier. The formulation was characterized in terms of chemical bonds and morphology using Fourier Transform Infrared (FTIR) Spectroscopy, Atomic Force Microscopy (AFM) and Proton Nuclear Magnetic Resonance (*HNMR) methods. According to our study insoluble BA could loaded well into ALGD. This loading caused an increase in the solubility rate of BA by more than 700-fold and a decrease in the toxicity effects to zero in vivo environment. Overall, BD at a dose of 40 mg/kg caused a significant decreased in the number of parasite (leishmania major (L. major)) in vitro and in vivo without inducing any toxic effect. © 2021. All Rights Reserved.

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Style	Citing Format
MLA	Mehrizi TZ, et al.. "A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer." Journal of Nanostructures, vol. 11, no. 1, 2021, pp. 143-152.
APA	Mehrizi TZ, Mosaffa N, Khamesipour A, Hoseini MHM, Shahmabadi HE, Ardestani MS, Ramezani A (2021). A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer. Journal of Nanostructures, 11(1), 143-152.
Chicago	Mehrizi TZ, Mosaffa N, Khamesipour A, Hoseini MHM, Shahmabadi HE, Ardestani MS, Ramezani A. "A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer." Journal of Nanostructures 11, no. 1 (2021): 143-152.
Harvard	Mehrizi TZ et al. (2021) 'A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer', Journal of Nanostructures, 11(1), pp. 143-152.
Vancouver	Mehrizi TZ, Mosaffa N, Khamesipour A, Hoseini MHM, Shahmabadi HE, Ardestani MS, et al.. A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer. Journal of Nanostructures. 2021;11(1):143-152.
BibTex	@article{ author = {Mehrizi TZ and Mosaffa N and Khamesipour A and Hoseini MHM and Shahmabadi HE and Ardestani MS and Ramezani A}, title = {A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer}, journal = {Journal of Nanostructures}, volume = {11}, number = {1}, pages = {143-152}, year = {2021} }
RIS	TY - JOUR AU - Mehrizi TZ AU - Mosaffa N AU - Khamesipour A AU - Hoseini MHM AU - Shahmabadi HE AU - Ardestani MS AU - Ramezani A TI - A Novel Nanoformulation for Reducing the Toxicity and Increasing the Efficacy of Betulinic Acid Using Anionic Linear Globular Dendrimer JO - Journal of Nanostructures VL - 11 IS - 1 SP - 143 EP - 152 PY - 2021 ER -

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