Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Use of Gabapentin in Management of Acute Pain After Surgery: Review of Literature



Eskandari AH1 ; Alipour S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Research, Deputy of Education, Ministry of Health and Medical Education, Tehran, Iran
  2. 2. Department of General Surgery, Breast Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Payavard Salamat Published:2019

Abstract

Background and Aim: Breast surgery is one of the most common surgical operations performed worldwide as well as in Iran. Acute postoperative pain is managed by different therapeutic modalities in these procedures, and opioid are the most frequently used option; however, their adverse consequences imposes restriction of use. The goal of this article is to review the effects of gabapentin on postoperative pain and opioid use in breast surgeries. Materials and Methods: PubMed, Ovid Medline, and Scopus databases from 2000 to 2019; as well as Google scholar, first 350 results, were searched for all clinical trials and review articles about the subject, using various related keywords. Sixty-two articles were reviewed by 2 researchers and finally data from 22 papers were gathered and assessed. Results: This review demonstrates that gabapentin is effective in reducing acute postoperative pain after breast operations. Also, rate of opioid consumption, an important objective in the period after surgery, is reduced by the use of opioids. Conclusion: This study prompts the effectiveness of gabapentin in controlling postoperative pain in breast operations; since this drug is very seldom used for this purpose in our country, we propose that medical staff consider it as a powerful option after breast procedures. © 2019, Tehran University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. A Cross-Sectional Study on the Postoperative Analgesic-Associated Side Effects and Clinical Parameters Following Partial Mastectomy, International Journal of Surgery Open (2020)
2. Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis, Frontiers in Nutrition (2022)
3. Resource Use and Costs Associated to the Initial Phase of Treatment for Patients With Colorectal Cancer Receiving Post-Surgery Chemotherapy: A Cost Analysis From a Healthcare Perspective, Iranian Journal of Public Health (2021)
4. Dendritic Cells Loaded With Exosomes Derived From Cancer Stem Cell-Enriched Spheroids As a Potential Immunotherapeutic Option, Journal of Cellular and Molecular Medicine (2021)
5. Early Breast Cancer Prediction Using Dermatoglyphics: Data Mining Pilot Study in a General Hospital in Iran, Health Education and Health Promotion (2021)
6. Clinical Applications of Nanomedicine in Cancer Therapy, Drug Discovery Today (2020)
7. Microfluidics for Detection of Exosomes and Micrornas in Cancer: State of the Art, Molecular Therapy Nucleic Acids (2022)
8. Nanoparticulate Systems for Dental Drug Delivery, Nanoengineered Biomaterials for Advanced Drug Delivery (2020)
Experts (# of related papers)
View all Related Experts
Ahmad Esmaillzadeh (2)
Ghazaleh Geraily (2)
Other Related Docs
9. Association Between Gastric Cancer and the Intake of Different Types of Iron and Meats, BMC Nutrition (2023)
10. A Decision Support System for Mammography Reports Interpretation, Health Information Science and Systems (2020)
11. Critical Involvement of Circular Rnas in Virus-Associated Cancers, Genes and Diseases (2023)
12. Global, Regional, and National Survey on the Burden and Quality of Care of Pancreatic Cancer: A Systematic Analysis for the Global Burden of Disease Study 1990–2017, Pancreatology (2021)
13. Comparison of Organs at Risk Doses Between Deep Inspiration Breath-Hold and Free-Breathing Techniques During Radiotherapy of Left-Sided Breast Cancer: A Meta-Analysis, Polish Journal of Medical Physics and Engineering (2022)
14. Factors Associated With Survival of Patients With Leukemia Using Penalized Splines and Comparing That With the Cox Proportional Hazards Model, Journal of Mazandaran University of Medical Sciences (2023)
15. Preemptive Analgesia With a Second Dose of Pregabalin, Acetaminophen, Naproxen, and Dextromethorphan: A Comparative Clinical Trial in Major Surgeries, Anesthesiology and Pain Medicine (2020)
16. Prevalence and Type Distribution of Human Papillomavirus Recovered From the Uterine Cervix of Nigerian Women: A Systematic Review and Meta-Analysis, Asian Pacific Journal of Cancer Prevention (2020)
17. Biological Landscape and Nanostructural View in Development and Reversal of Oxaliplatin Resistance in Colorectal Cancer, Translational Oncology (2024)
18. Dosimetric Effect of Nanoparticles in the Breast Cancer Treatment Using Intrabeam® System With Spherical Applicators in the Presence of Tissue Heterogeneities: A Monte Carlo Study, Biomedical Physics and Engineering Express (2021)
19. Circular Rnas (Circrnas) in Cancer Proliferation: Molecular Interactions and Possible Therapeutic Targets, Non-coding RNA Transcripts In Cancer Therapy: Pre-clinical And Clinical Implications (2023)
20. Comprehensive Assessment of Nutritional Status and Nutritional-Related Complications in Newly Diagnosed Esophageal Cancer Patients: A Cross-Sectional Study, Clinical Nutrition (2021)
21. Dietary Intake of Branched-Chain Amino Acids in Relation to the Risk of Breast Cancer, Breast Cancer (2022)
22. Improvement in the Survival of Esophageal Cancer Patients at Cancer Institute of Iran After Implementation of the Neo-Adjuvant Chemo-Radiation: Retrospective Cohort Study, Middle East Journal of Cancer (2021)
23. Multi-Modal Preemptive Analgesia With Pregabalin, Acetaminophen, Naproxen, and Dextromethorphan in Radical Neck Dissection Surgery: A Randomized Clinical Trial, Anesthesiology and Pain Medicine (2016)
24. The Effect of Preoperative Gabapentin on Pain Severity After Posterior Urethral Surgery: A Randomized, Double-Blind, Placebo-Controlled Study, Urology Journal (2020)