Breastmilk Feeding Practices Are Associated With the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: The Child Cohort Study

Breastmilk Feeding Practices Are Associated With the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: The Child Cohort Study Publisher Pubmed

Fehr K^{1, 2} ; Moossavi S^{1, 3, 4} ; Sbihi H⁵ ; Boutin RCT^{6, 7} ; Bode L⁸ ; Robertson B⁸ ; Yonemitsu C⁸ ; Field CJ⁹ ; Becker AB^{1, 2, 4} ; Mandhane PJ¹⁰ ; Sears MR¹¹ ; Khafipour E¹² ; Moraes TJ¹³ ; Subbarao P^{13, 14} Show All Authors

Fehr K^{1, 2}
Moossavi S^{1, 3, 4}
Sbihi H⁵
Boutin RCT^{6, 7}
Bode L⁸
Robertson B⁸
Yonemitsu C⁸
Field CJ⁹
Becker AB^{1, 2, 4}
Mandhane PJ¹⁰
Sears MR¹¹
Khafipour E¹²
Moraes TJ¹³
Subbarao P^{13, 14}
Finlay BB^{6, 7, 15}
Turvey SE⁵
Azad MB^{1, 2}

Show Affiliations

1. Children's Hospital Research Institute of Manitoba and Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Winnipeg, MB, Canada
2. Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada
3. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada
4. Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada
6. Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
7. Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
8. Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California San Diego, La Jolla, CA, United States
9. Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada
10. Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
11. Department of Medicine, McMaster University, Hamilton, ON, Canada
12. Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada
13. Department of Pediatrics Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
14. Department of Physiology, University of Toronto, Toronto, ON, Canada
15. Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada

Source: Cell Host and Microbe Published:2020

Abstract

Fehr et al. analyze infant gut microbiota in the CHILD cohort and identify associations with breastmilk feeding practices (exclusivity, duration, and pumping) and breastmilk microbiota. Within mother-infant dyads, co-occurrence of bacteria in breastmilk and stool suggests bacteria in breastmilk may transfer to the infant and influence the developing gut microbiota. © 2020 Elsevier Inc.; Gut microbiota play a critical role in infant health. It is now accepted that breastmilk contains live bacteria from endogenous and exogenous sources, but it remains unclear whether these bacteria transfer to the infant gut and whether this process is influenced by breastmilk feeding practices. Here, we show that certain bacteria, including Streptococcus spp. and Veillonella dispar, co-occur in mothers’ milk and their infants’ stool, and co-occurrence is reduced when infants receive pumped breastmilk. The relative abundances of commonly shared species are positively correlated between breastmilk and stool. Overall, gut microbiota composition is strongly associated with breastfeeding exclusivity and duration but not breastmilk feeding mode (nursing versus pumping). Moreover, breastmilk bacteria contributed to overall gut microbiota variation to a similar extent as other modifiers of the infant microbiome, such as birth mode. These results provide evidence that breastmilk may transfer bacteria to the infant gut and influence microbiota development. © 2020 Elsevier Inc.

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Style	Citing Format
MLA	Fehr K, et al.. "Breastmilk Feeding Practices Are Associated With the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: The Child Cohort Study." Cell Host and Microbe, vol. 28, no. 2, 2020, pp. 285-297.e4.
APA	Fehr K, Moossavi S, Sbihi H, Boutin RCT, Bode L, Robertson B, Yonemitsu C, Field CJ, Becker AB, Mandhane PJ, Sears MR, Khafipour E, Moraes TJ, Subbarao P, Finlay BB, Turvey SE, Azad MB (2020). Breastmilk Feeding Practices Are Associated With the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: The Child Cohort Study. Cell Host and Microbe, 28(2), 285-297.e4.
Chicago	Fehr K, Moossavi S, Sbihi H, Boutin RCT, Bode L, Robertson B, Yonemitsu C, et al.. "Breastmilk Feeding Practices Are Associated With the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: The Child Cohort Study." Cell Host and Microbe 28, no. 2 (2020): 285-297.e4.
Harvard	Fehr K et al. (2020) 'Breastmilk Feeding Practices Are Associated With the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: The Child Cohort Study', Cell Host and Microbe, 28(2), pp. 285-297.e4.
Vancouver	Fehr K, Moossavi S, Sbihi H, Boutin RCT, Bode L, Robertson B, et al.. Breastmilk Feeding Practices Are Associated With the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: The Child Cohort Study. Cell Host and Microbe. 2020;28(2):285-297.e4.
BibTex	@article{ author = {Fehr K and Moossavi S and Sbihi H and Boutin RCT and Bode L and Robertson B and Yonemitsu C and Field CJ and Becker AB and Mandhane PJ and Sears MR and Khafipour E and Moraes TJ and Subbarao P and Finlay BB and Turvey SE and Azad MB}, title = {Breastmilk Feeding Practices Are Associated With the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: The Child Cohort Study}, journal = {Cell Host and Microbe}, volume = {28}, number = {2}, pages = {285-297.e4}, year = {2020} }
RIS	TY - JOUR AU - Fehr K AU - Moossavi S AU - Sbihi H AU - Boutin RCT AU - Bode L AU - Robertson B AU - Yonemitsu C AU - Field CJ AU - Becker AB AU - Mandhane PJ AU - Sears MR AU - Khafipour E AU - Moraes TJ AU - Subbarao P AU - Finlay BB AU - Turvey SE AU - Azad MB TI - Breastmilk Feeding Practices Are Associated With the Co-Occurrence of Bacteria in Mothers’ Milk and the Infant Gut: The Child Cohort Study JO - Cell Host and Microbe VL - 28 IS - 2 SP - 285 EP - 297.e4 PY - 2020 ER -

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