Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors

Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors Publisher Pubmed

Moossavi S^{1, 2, 3, 4} ; Sepehri S² ; Robertson B⁵ ; Bode L^{5, 6} ; Goruk S⁷ ; Field CJ⁷ ; Lix LM⁸ ; De Souza RJ^{9, 10, 11} ; Becker AB^{2, 3} ; Mandhane PJ¹² ; Turvey SE¹³ ; Subbarao P^{14, 15} ; Moraes TJ¹⁴ ; Lefebvre DL¹⁶ Show All Authors

Moossavi S^{1, 2, 3, 4}
Sepehri S²
Robertson B⁵
Bode L^{5, 6}
Goruk S⁷
Field CJ⁷
Lix LM⁸
De Souza RJ^{9, 10, 11}
Becker AB^{2, 3}
Mandhane PJ¹²
Turvey SE¹³
Subbarao P^{14, 15}
Moraes TJ¹⁴
Lefebvre DL¹⁶
Sears MR¹⁶
Khafipour E^{2, 17}
Azad MB^{2, 3}

Show Affiliations

1. Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada
2. Children's Hospital Research Institute of Manitoba, Pediatrics and Child Health, Winnipeg, MB, Canada
3. Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Winnipeg, MB, Canada
4. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Pediatrics, University of California, La Jolla, San Diego, CA, United States
6. Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California, La Jolla, San Diego, CA, United States
7. Agricultural Food, and Nutritional Science, University of Alberta, Edmonton, AB, Canada
8. Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada
9. Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
10. Nutritional Sciences, University of Toronto, Toronto, ON, Canada
11. Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada
12. Pediatrics, University of Alberta, Edmonton, AB, Canada
13. Pediatrics, University of British Columbia, Vancouver, BC, Canada
14. Division of Respiratory Medicine, Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
15. Physiology, University of Toronto, Toronto, ON, Canada
16. Medicine, McMaster University, Hamilton, ON, Canada
17. Animal Science, University of Manitoba, Winnipeg, MB, Canada

Source: Cell Host and Microbe Published:2019

Abstract

Breastmilk contains a complex community of bacteria that may help seed the infant gut microbiota. The composition and determinants of milk microbiota are poorly understood. Among 393 mother-infant dyads from the CHILD cohort, we found that milk microbiota at 3–4 months postpartum was dominated by inversely correlated Proteobacteria and Firmicutes, and exhibited discrete compositional patterns. Milk microbiota composition and diversity were associated with maternal factors (BMI, parity, and mode of delivery), breastfeeding practices, and other milk components in a sex-specific manner. Causal modeling identified mode of breastfeeding as a key determinant of milk microbiota composition. Specifically, providing pumped breastmilk was consistently associated with multiple microbiota parameters including enrichment of potential pathogens and depletion of bifidobacteria. Further, these data support the retrograde inoculation hypothesis, whereby the infant oral cavity impacts the milk microbiota. Collectively, these results identify features and determinants of human milk microbiota composition, with potential implications for infant health and development. © 2019 Elsevier Inc.; Moossavi et al. examine human milk microbiota in the CHILD birth cohort and use causal modeling to describe sex-specific associations with maternal, infant, and early-life factors. A strong association with feeding method (i.e., pumped versus directly at the breast) suggests some milk bacteria originate from the infant oral cavity. © 2019 Elsevier Inc.

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Style	Citing Format
MLA	Moossavi S, et al.. "Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors." Cell Host and Microbe, vol. 25, no. 2, 2019, pp. 324-335.e4.
APA	Moossavi S, Sepehri S, Robertson B, Bode L, Goruk S, Field CJ, Lix LM, De Souza RJ, Becker AB, Mandhane PJ, Turvey SE, Subbarao P, Moraes TJ, Lefebvre DL, Sears MR, Khafipour E, Azad MB (2019). Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors. Cell Host and Microbe, 25(2), 324-335.e4.
Chicago	Moossavi S, Sepehri S, Robertson B, Bode L, Goruk S, Field CJ, Lix LM, et al.. "Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors." Cell Host and Microbe 25, no. 2 (2019): 324-335.e4.
Harvard	Moossavi S et al. (2019) 'Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors', Cell Host and Microbe, 25(2), pp. 324-335.e4.
Vancouver	Moossavi S, Sepehri S, Robertson B, Bode L, Goruk S, Field CJ, et al.. Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors. Cell Host and Microbe. 2019;25(2):324-335.e4.
BibTex	@article{ author = {Moossavi S and Sepehri S and Robertson B and Bode L and Goruk S and Field CJ and Lix LM and De Souza RJ and Becker AB and Mandhane PJ and Turvey SE and Subbarao P and Moraes TJ and Lefebvre DL and Sears MR and Khafipour E and Azad MB}, title = {Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors}, journal = {Cell Host and Microbe}, volume = {25}, number = {2}, pages = {324-335.e4}, year = {2019} }
RIS	TY - JOUR AU - Moossavi S AU - Sepehri S AU - Robertson B AU - Bode L AU - Goruk S AU - Field CJ AU - Lix LM AU - De Souza RJ AU - Becker AB AU - Mandhane PJ AU - Turvey SE AU - Subbarao P AU - Moraes TJ AU - Lefebvre DL AU - Sears MR AU - Khafipour E AU - Azad MB TI - Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors JO - Cell Host and Microbe VL - 25 IS - 2 SP - 324 EP - 335.e4 PY - 2019 ER -

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