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Endocrine Disorders in Thalassemia Major Patients: A Review



Hamidi Z1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Kuwait Medical Journal Published:2016

Abstract

Recently, due to increased thalassemia major (TM) patients’ life expectancy, the issue of endocrine disorders in children, adolescents and young adults with TM has attracted much attention as a prominent cause of morbidity despite adequate transfusion and iron chelation therapy. Frequency of one endocrinopathy, two simultaneous endocrinopathy, and patients with three endocrine disorders, reported 40.0%, 26.7% and 6.7%, respectively. The main risk factor of endocrine disorders is iron overload due to multitransfusion. An overview of thalassemia major, effects of iron overload on endocrine system as a whole and one by one - are included in this review. Also some points about management of endocrinopathies in these patients, mentioned at the end. © The Kuwait Medical Journal. All rights reserved.
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