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How Age, Sex and Transfusion Affects the Incidence of Endocrine and Bone Density Disorders in Major Thalassemic Patients



Mohajeritehrani MR1 ; Alemzadeh SA1 ; Marzbali FA1 ; Nasserisina S1 ; Hosnan F1 ; Naghghash A2 ; Hamidieh AA3 ; Behfar M3 ; Mohseni F1 ; Rashidian H1 ; Shirazi S4 ; Aboeerad M1 ; Qorbani M5 ; Larijani B2 Show All Authors
Authors
  1. Mohajeritehrani MR1
  2. Alemzadeh SA1
  3. Marzbali FA1
  4. Nasserisina S1
  5. Hosnan F1
  6. Naghghash A2
  7. Hamidieh AA3
  8. Behfar M3
  9. Mohseni F1
  10. Rashidian H1
  11. Shirazi S4
  12. Aboeerad M1
  13. Qorbani M5
  14. Larijani B2
  15. Hamidi Z1
Show Affiliations
Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Thalassemia Department, Torfeh Hospital, Shahid Beheshti University, Tehran, Iran
  3. 3. Pediatric Stem Cell Transplant Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Non-communicable Diseases Research Center, Alborz University of Medical Science, Karaj, Iran

Source: Iranian Journal of Public Health Published:2024

Abstract

Background: Beta-thalassemia major patients frequently have endocrinopathies. We tried to determine relation between demographic and transfusion factor and endocrinopathies. Methods: Major beta-thalassemia patients (n=114 cases), 3–38 yr of age, entered this study. Female to male ratio was 51/63. Children (less than 20 yr) formed 57% of participants. Information about bone mineral density (BMD) and hormonal and biochemistry blood evaluation including fasting blood sugar (FBS), ferritin, triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH), testosterone (males), and estradiol (females) entered data sheet. Results: Sex and ferritin level showed no significant correlation with above disorders. Age significantly correlated to short stature, diabetes, low BMD at femur and neck (P, 0.031, 0.008, 0.009 and <0.001, respectively). The risk of short stature had increased in 12 yr and older patients 7.71 times than younger patients (P= 0.008). The risk of diabetes had increased in 35 yr and older patients 26.25 times than younger patients (P= 0.03). The risk of Z-score ≤-2 in femoral region has increased in 19 yr and older patients 5.84 times than younger patients (P= 0.002). The risk of Z-score ≤-2 in spinal region has increased in 14 yr and older patients 17 times than younger patients (P= 0.007). Conclusion: The main factor related with endocrinopathies was age. The correlation between age and short stature, diabetes and low BMD was positive. Therefore, we recommend early monitoring of thalassemia patients (in their late childhood and early teenage) for these complications. © 2024 Mohajeri-Tehrani et al. Published by Tehran University of Medical Sciences.
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