Comparison of Bone Mineral Density Changes in Pediatric Thalassemic Patients With and Without Hematopoietic Stem Cell Transplant Publisher Pubmed



Hamidieh AA¹ ; Mohajeritehrani MR² ; Behfar M¹ ; Vagharimeher N² ; Alimoghaddam K¹ ; Mohseni F² ; Ghavamzadeh A¹ ; Larijani B² ; Hamidi Z² Show Affiliations
Source: Experimental and Clinical Transplantation Published:2015

Abstract

Objectives: Beta thalassemia major is a genetic hemoglobin disorder that affects bone density. The disease leads to deteriorating bone structure but can be treated with hematopoietic stem cell transplant. We aimed to assess bone mineral density changes in pediatric beta thalassemia major patients who had undergone a hematopoietic stem cell transplant compared with similarly affected patients who had not undergone a hematopoietic stem cell transplant. Materials and Methods: Forty beta thalassemia major patients, 20 transplant and 20 nontransplant, younger than 16 years of age were enrolled. The mean age of transplant patients was 8.15 years and nontransplant patients was 9.5 years (P = .242). The female:male ratio was 1:1 in both groups. None of the patients reached puberty during this study. Bone mineral density was evaluated in transplant patients before and 1 year after hematopoietic stem cell transplant. Bone mineral density of nontransplant patients also was evaluated 1 year after their initial bone mineral density test. A Norland XR-46 densitometer was used to make all bone mineral density measurements. None of the patients had a z score < -2. Results: Mean bone mineral density changes in the femur and spine during this study were 0.008 ± 0.075 g/cm 2 and 0.048 ± 0.045 g/cm 2 in transplant patients and 0.045 ± 0.072 g/cm 2 and 0.036 ± 0.058 g/cm2 in nontransplant patients. No significant differences between bone mineral density changes in transplant and nontransplant patients were detected during the study. Conclusions: No significant effects on bone mineral density were detected in hematopoietic stem cell transplant pediatric beta thalassemia major patients compared with similarly affected nontransplant patients. Studies of longer duration may be required to identify significant changes in bone mineral density in hematopoietic stem cell transplant patients. © Baskent University 2015 Printed in Turkey. All Rights Reserved.