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The Role of Fibromodulin in Cancer Pathogenesis: Implications for Diagnosis and Therapy Publisher



Pourhanifeh MH1 ; Mohammadi R2 ; Noruzi S2 ; Hosseini SA2 ; Fanoudi S3 ; Mohamadi Y4 ; Hashemzehi M5, 6 ; Asemi Z1 ; Mirzaei HR7 ; Salarinia R2 ; Mirzaei H1
Authors

Source: Cancer Cell International Published:2019


Abstract

Fibromodulin (FMOD) is known as one of very important extracellular matrix small leucine-rich proteoglycans. This small leucine-rich proteoglycan has critical roles in the extracellular matrix organization and necessary for repairing of tissue in many organs. Given that the major task of FMOD is the modulation of collagen fibrillogenesis. However, recently observed that FMOD plays very important roles in the modulation of a variety of pivotal biological processes including angiogenesis, regulation of TGF-β activity, and differentiation of human fibroblasts into pluripotent cells, inflammatory mechanisms, apoptosis and metastatic related phenotypes. Besides these roles, FMOD has been considered as a new tumor-related antigen in some malignancies such as lymphoma, leukemia, and leiomyoma. Taken together, these findings proposed that FMOD could be introduced as diagnostic and therapeutic biomarkers in treatment of various cancers. Herein, for first time, we highlighted the various roles of FMOD in the cancerous conditions. Moreover, we summarized the diagnostic and therapeutic applications of FMOD in cancer therapy. © 2019 The Author(s).
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