The Prognostic and Therapeutic Value and Clinical Implications of Fibroblast Activation Protein-Α As a Novel Biomarker in Colorectal Cancer Publisher Pubmed



Kalaei Z¹ ; Manafifarid R² ; Rashidi B³ ; Kiani FK³ ; Zarei A³ ; Fathi M⁴ ; Jadidiniaragh F^{3, 4, 5} Show Affiliations
Source: Cell Communication and Signaling Published:2023

Abstract

The identification of contributing factors leading to the development of Colorectal Cancer (CRC), as the third fatal malignancy, is crucial. Today, the tumor microenvironment has been shown to play a key role in CRC progression. Fibroblast-Activation Protein-α (FAP) is a type II transmembrane cell surface proteinase expressed on the surface of cancer-associated fibroblasts in tumor stroma. As an enzyme, FAP has di- and endoprolylpeptidase, endoprotease, and gelatinase/collagenase activities in the Tumor Microenvironment (TME). According to recent reports, FAP overexpression in CRC contributes to adverse clinical outcomes such as increased lymph node metastasis, tumor recurrence, and angiogenesis, as well as decreased overall survival. In this review, studies about the expression level of FAP and its associations with CRC patients' prognosis are reviewed. High expression levels of FAP and its association with clinicopathological factors have made as a potential target. In many studies, FAP has been evaluated as a therapeutic target and diagnostic factor into which the current review tries to provide a comprehensive insight. [MediaObject not available: see fulltext.]. © 2023, The Author(s).