Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Nbs Superfood: A Promising Adjunctive Therapy in Critically Ill Icu Patients With Omicron Variant of Covid-19 Publisher



Mosadegh M1 ; Khalkhali A2 ; Erfani Y3 ; Nezamdoost M4 ; Hashemi SH5 ; Azizi Jalilian F6, 7 ; Ansari N6 ; Mahmoudvand S6 ; Mamani M5 ; Abdoli E5 ; Amini R7 ; Kalvandi G8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Science, Faculty of Biology, Islamic Azad University, Mashhad, Iran
  3. 3. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, Division of Infectious Disease, Farabi Hospital, Social Security Organization, Mashhad, Iran
  5. 5. Department of Infectious Diseases, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Department of Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  7. 7. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  8. 8. Department of Pediatrics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Source: AMB Express Published:2024


Abstract

This clinical trial aimed to assess the impact of Nutrition Bio-shield superfood (NBS) on clinical status among critically ill ICU patients suffering from acute respiratory distress syndrome (ARDS) due to the Omicron variant of COVID-19. A total of 400 patients with confirmed Omicron-related ARDS were randomly assigned to either the intervention group (n = 200) or the control group (n = 200). Patients in the intervention group received 1.5 g of NBS powder daily for 2 weeks in addition to standard antiviral treatment, while the control group received a placebo alongside standard antiviral therapy. Serum samples were collected from all patients in both groups, and various clinical and laboratory parameters, including ESR, CRP, D-Dimer, CPK, WBC count, lymphocyte count, and lymphocyte percentage, were measured using established methodologies. Following a 14-day intervention period, the intervention group exhibited a significant reduction in mean serum levels of CRP (15.39 vs. 48.49; P < 0.001), ESR (14.28 vs. 34.03; P < 0.001), D-Dimer (485.18 vs. 1009.13; P = 0.001), and CPK (68.93 vs. 131.48; P < 0.001) compared to the control group. Conversely, a significant increase was observed in the mean serum levels of lymphocytes (1537.06 vs. 1152.60; P < 0.001) in the intervention group after 14 days of treatment compared to the control group. The remarkable reduction in inflammatory markers and mortality rates observed with NBS supplementation alongside standard antiviral treatment underscores its crucial role in mitigating inflammation and achieving an important milestone in the fight against COVID-19. © The Author(s) 2024.
Related Docs
View other Related Docs
1. The Effect of Nutrition Bio-Shield Superfood (Nbs) on Disease Severity and Laboratory Biomarkers in Patients With Covid-19: A Randomized Clinical Trial, Microbial Pathogenesis (2022)
2. A Novel Therapeutic Approach for Hormonal Imbalance in Polycystic Ovarian Syndrome; Evaluating the Effects of Nutrition Bio-Shield Supplement in an Animal Model, Obesity Medicine (2025)
3. A Comprehensive Insight Into Apoptosis: Molecular Mechanisms, Signaling Pathways, and Modulating Therapeutics, Cancer Investigation (2025)
4. Serum C-Reactive Protein Greater Than 75 Mg/Dl As an Early Available Laboratory Predictor of Severe Covid-19: A Systematic Review, Immunity# Inflammation and Disease (2023)
5. The Evaluation of Hematological Parameters and Their Correlation With Disease Prognosis in Covid-19 Disease in Iran, International Journal of Hematology-Oncology and Stem Cell Research (2023)
6. Sars-Cov-2 Omicron (B.1.1.529) Variant: A Challenge With Covid-19, Diagnostics (2023)
7. The Role of Bacterial and Fungal Human Respiratory Microbiota in Covid-19 Patients, BioMed Research International (2021)
8. Post-Discharge Thromboembolic Events in Covid-19 Patients: A Review on the Necessity for Prophylaxis, Clinical and Applied Thrombosis/Hemostasis (2023)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (3)
Yousef Erfani (3)
Other Related Docs
9. Recent Findings on the Coronavirus Disease 2019 (Covid-19); Immunopathogenesis and Immunotherapeutics, International Immunopharmacology (2020)
10. Covid-19 and Multiorgan Failure: A Narrative Review on Potential Mechanisms, Journal of Molecular Histology (2020)
11. Immunopathological Similarities Between Covid-19 and Influenza: Investigating the Consequences of Co-Infection, Microbial Pathogenesis (2021)
12. Covid-19 Infection in Heart Transplant Recipients: Results of a Six-Month Prospective Survey-Based Study, Acta Medica Iranica (2022)
13. Covid-19 Infection and Stroke Risk, Reviews in the Neurosciences (2021)
14. A Borderless Solution Is Needed for a Borderless Complexity, Like Covid-19, the Universal Invader, Advances in Experimental Medicine and Biology (2021)
15. Can Anti-Parasitic Drugs Help Control Covid-19?, Future Virology (2022)
16. An Overview on the Treatments and Prevention Against Covid-19, Virology Journal (2023)
17. Pathogenesis, Clinical Manifestations and Complications of Coronavirus Disease 2019 (Covid-19), Future Microbiology (2020)
18. Pathological Effects of Sars-Cov-2 on Hematological and Immunological Cells: Alterations in Count, Morphology, and Function, Pathology Research and Practice (2022)
19. Severe Acute Respiratory Syndrome-Coronavirus-2 Spike (S) Protein Based Vaccine Candidates: State of the Art and Future Prospects, Reviews in Medical Virology (2021)
20. Obesity Paradox: Does It Lengthen Survival in Iranian Covid Patients?, Nutrition Today (2022)
21. Risk Factors for Adverse Outcomes of Covid-19 Patients: Possible Basis for Diverse Responses to the Novel Coronavirus Sars-Cov-2, Life Sciences (2021)
22. Evaluation of Blood Biochemistry and Cardiopulmonary Status of Hospitalized Covid-19 Patients in 3 Months Post Discharged Follow up Survey, Clinical Medicine Insights: Circulatory# Respiratory and Pulmonary Medicine (2022)
23. Venous Thromboembolism in Viral Diseases: A Comprehensive Literature Review, Health Science Reports (2023)
24. Biomarker Based Biosensors: An Opportunity for Diagnosis of Covid-19, Reviews in Medical Virology (2022)
25. Immunomodulatory-Based Therapy As a Potential Promising Treatment Strategy Against Severe Covid-19 Patients: A Systematic Review, International Immunopharmacology (2020)
26. Covid-19: Our Current Knowledge of Epidemiology, Pathology, Therapeutic Approaches, and Diagnostic Methods, Anti-Cancer Agents in Medicinal Chemistry (2021)
27. Remdesivir: A Beacon of Hope From Ebola Virus Disease to Covid-19, Reviews in Medical Virology (2020)
28. Review on Oxidative Stress Relation on Covid-19: Biomolecular and Bioanalytical Approach, International Journal of Biological Macromolecules (2021)
29. The Relationship of Covid-19 Severity With Laboratory Findings and Neutrophil-To-Lymphocyte Ratio in Patients Admitted to a Large Teaching Hospital in Iran: A Cross-Sectional Study, Health Science Reports (2024)
30. Covid-19 Pandemic and Periodontal Practice: The Immunological, Clinical, and Economic Points of View, BioMed Research International (2022)
31. Covid-19 in Patients With Rheumatic Disease Using Immunomodulatory Drugs: Imaging Findings and Predictors of Hospitalization, Rheumatology and Therapy (2023)