The Possible Role of Sirtuins and Mirnas in Gastrointestinal Cancers: Special Focus on Sirt1 Publisher



Meybodi SM ; Bahreini F ; Kalies K ; Reiter RJ ; Rezaei N
Source: Cancer Cell International Published:2026

Abstract

This review comprehensively examines the role of Sirtuins and microRNAs (miRNAs) in gastrointestinal cancers (GICs) with a particular focus on Sirt1. Gastrointestinal malignancies, comprising a wide range of tumors within the digestive tract, represent an essential health challenge worldwide, and are distinguished by high incidence and mortality rates. Emerging evidence implies that Sirtuins, particularly SIRT1, act as a double-edged sword in cancer biology, acting as either tumor promoters or suppressors, depending on the cellular milieu. miRNAs also have been identified as critical regulators of gene expression, impacting cancer progression through their interaction with Sirtuins. A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and Google Scholar to identify relevant studies on the topic. This review highlights the complex relationships between Sirtuins and miRNAs in GICs, exploring their potential as biomarkers for early detection and targets for therapeutic intervention. The regulatory mechanisms of miRNAs in the Sirtuin family, specifically in human GICs, are examined to identify their influence on cancer diagnosis, progression, and management. The results may ultimately serve as a basis for developing diagnostic markers for the early detection of GICs. © The Author(s) 2026.