Mirnas and Exosomal Mirnas in Lung Cancer: New Emerging Players in Tumor Progression and Therapy Response Publisher Pubmed



Hashemi M^{1, 2} ; Khosroshahi EM¹ ; Chegini MK¹ ; Abedi M³ ; Matinahmadi A⁴ ; Hosnarody YSD¹ ; Rezaei M⁵ ; Saghari Y¹ ; Fattah E⁶ ; Abdi S⁷ ; Entezari M^{1, 2} ; Nabavi N⁸ ; Rashidi M^{9, 10} ; Raesi R^{11, 12} Show All Authors Show Affiliations
Source: Pathology Research and Practice Published:2023

Abstract

Non-coding RNAs have shown key roles in cancer and among them, short RNA molecules are known as microRNAs (miRNAs). These molecules have length less than 25 nucleotides and suppress translation and expression. The functional miRNAs are produced in cytoplasm. Lung cancer is a devastating disease that its mortality and morbidity have undergone an increase in recent years. Aggressive behavior leads to undesirable prognosis and tumors demonstrate abnormal proliferation and invasion. In the present review, miRNA functions in lung cancer is described. miRNAs reduce/increase proliferation and metastasis. They modulate cell death and proliferation. Overexpression of oncogenic miRNAs facilitates drug resistance and radio-resistance in lung cancer. Tumor microenvironment components including macrophages and cancer-associated fibroblasts demonstrate interactions with miRNAs in lung cancer. Other factors such as HIF-1α, lncRNAs and circRNAs modulate miRNA expression. miRNAs have also value in the diagnosis of lung cancer. Understanding such interactions can pave the way for developing novel therapeutics in near future for lung cancer patients. © 2023 Elsevier GmbH