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Nrf2 Signaling Pathway: A Comprehensive Prognostic and Gene Expression Profile Analysis in Breast Cancer Publisher Pubmed



Soghli N1 ; Yousefi H2, 3 ; Naderi T4 ; Fallah A5 ; Moshksar A6 ; Darbeheshti F7 ; Vittori C3 ; Delavar MR8 ; Zare A9 ; Rad HS10 ; Kazemi A11 ; Bitaraf A12 ; Hussen BM13 ; Taheri M14, 15 Show All Authors
Authors
  1. Soghli N1
  2. Yousefi H2, 3
  3. Naderi T4
  4. Fallah A5
  5. Moshksar A6
  6. Darbeheshti F7
  7. Vittori C3
  8. Delavar MR8
  9. Zare A9
  10. Rad HS10
  11. Kazemi A11
  12. Bitaraf A12
  13. Hussen BM13
  14. Taheri M14, 15
  15. Jamali E16
Show Affiliations
Authors Affiliations
  1. 1. Babol University of Medical Sciences, Faculty of Dentistry, Babol, Iran
  2. 2. Louisiana State University Health Science Center (LSUHSC), Biochemistry & Molecular Biology, New Orleans, LA, United States
  3. 3. Stanley S. Scott Cancer Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, United States
  4. 4. Department of Laboratory Hematology and Blood Bank, School of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of hematology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. University of Texas Medical Branch (UTMB), Interventional Radiology, Galveston, TX, United States
  7. 7. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
  9. 9. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD, Australia
  11. 11. Fasa University of Medical Sciences, School of Medicine, Fasa, Iran
  12. 12. Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  13. 13. Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq
  14. 14. Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  15. 15. Institute of Human Genetics, Jena University Hospital, Jena, Germany
  16. 16. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Breast cancer is the most frequently diagnosed malignant tumor in women and a major public health concern. NRF2 axis is a cellular protector signaling pathway protecting both normal and cancer cells from oxidative damage. NRF2 is a transcription factor that binds to the gene promoters containing antioxidant response element-like sequences. In this report, differential expression of NRF2 signaling pathway elements, as well as the correlation of NRF2 pathway mRNAs with various clinicopathologic characteristics, including molecular subtypes, tumor grade, tumor stage, and methylation status, has been investigated in breast cancer using METABRIC and TCGA datasets. In the current report, our findings revealed the deregulation of several NRF2 signaling elements in breast cancer patients. Moreover, there were negative correlations between the methylation of NRF2 genes and mRNA expression. The expression of NRF2 genes significantly varied between different breast cancer subtypes. In conclusion, substantial deregulation of NRF2 signaling components suggests an important role of these genes in breast cancer. Because of the clear associations between mRNA expression and methylation status, DNA methylation could be one of the mechanisms that regulate the NRF2 pathway in breast cancer. Differential expression of Hippo genes among various breast cancer molecular subtypes suggests that NRF2 signaling may function differently in different subtypes of breast cancer. Our data also highlights an interesting link between NRF2 components' transcription and tumor grade/stage in breast cancer. © 2023 Elsevier GmbH
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