Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway

Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway Publisher Pubmed

Hosseini H¹ ; Teimouri M¹ ; Shabani M¹ ; Koushki M¹ ; Babaei Khorzoughi R¹ ; Namvarjah F¹ ; Izadi P² ; Meshkani R¹

Show Affiliations

1. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Biochemistry and Cell Biology Published:2020

Abstract

Recent findings have demonstrated the aberrant DNA methylation of the Nrf2-Keap1 genes in human cancers; however, the epigenetic control of this pathway in non-alcoholic fatty liver disease (NAFLD) is unknown. Resveratrol can modify epigenetic mechanisms. Our objectives in this study were to explore the correlation between promoter methylation of the Nrf2-Keap1 genes and NAFLD, and that investigate the effect of resveratrol on the epigenetic regulation Nrf2-Keap1 in vitro and in vivo models of NAFLD. Resveratrol attenuated high fat-diet (HFD)-induced methylation of the Nrf2 promoter in the liver of mice, and this effect was correlated with reduction in triglyceride level and decrease in the expression of lipogenesis-related genes such as FAS and SREBP-1c. In addition, treatment of HepG2 cells with high glucose (HG) enhanced methylation level of the Nrf2 promoter, whereas resveratrol reversed this effect. Treatment of the cells with resveratrol or 5-aza, a demethylating agent, could prevent HG-induced reactive oxygen species production and expression of Nrf2-controlled antioxidant genes. Moreover, resveratrol or 5-aza could significantly attenuate HG-induced triglyceride accumulation in HepG2 cells. These findings indicate that resveratrol attenuates NAFLD through the epigenetic modification the Nrf2 signaling. © 2019 Elsevier Ltd

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Farshid Noorbakhsh (3)

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Style	Citing Format
MLA	Hosseini H, et al.. "Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway." International Journal of Biochemistry and Cell Biology, vol. 119, no. , 2020, pp. -.
APA	Hosseini H, Teimouri M, Shabani M, Koushki M, Babaei Khorzoughi R, Namvarjah F, Izadi P, Meshkani R (2020). Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway. International Journal of Biochemistry and Cell Biology, 119(), -.
Chicago	Hosseini H, Teimouri M, Shabani M, Koushki M, Babaei Khorzoughi R, Namvarjah F, Izadi P, Meshkani R. "Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway." International Journal of Biochemistry and Cell Biology 119, no. (2020): -.
Harvard	Hosseini H et al. (2020) 'Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway', International Journal of Biochemistry and Cell Biology, 119(), pp. -.
Vancouver	Hosseini H, Teimouri M, Shabani M, Koushki M, Babaei Khorzoughi R, Namvarjah F, et al.. Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway. International Journal of Biochemistry and Cell Biology. 2020;119():-.
BibTex	@article{ author = {Hosseini H and Teimouri M and Shabani M and Koushki M and Babaei Khorzoughi R and Namvarjah F and Izadi P and Meshkani R}, title = {Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway}, journal = {International Journal of Biochemistry and Cell Biology}, volume = {119}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Hosseini H AU - Teimouri M AU - Shabani M AU - Koushki M AU - Babaei Khorzoughi R AU - Namvarjah F AU - Izadi P AU - Meshkani R TI - Resveratrol Alleviates Non-Alcoholic Fatty Liver Disease Through Epigenetic Modification of the Nrf2 Signaling Pathway JO - International Journal of Biochemistry and Cell Biology VL - 119 IS - SP - EP - PY - 2020 ER -

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