Corneal Patch Graft: A New Approach for Scleral Necrosis Secondary to Plaque Radiotherapy Publisher Pubmed



Naseripour M^{1, 5} ; Aghaei H¹ ; Sedaghat A¹ ; Kheirkhah A² ; Jaberi R³ ; Azma Z⁴ Show Affiliations
Source: Cornea Published:2016

Abstract

Purpose: To evaluate the anatomical outcomes of corneal patch grafts in patients with progressive scleral necrosis secondary to plaque radiotherapy used for uveal malignant melanoma management. Methods: In this case series, 4 patients with progressive scleral necrosis after Ru-106 plaque radiotherapy underwent corneal patch grafts with the anterior corneal button from Descemet stripping automated endothelial keratoplasty donor tissue to strengthen the sclera and to improve appearance of the eye. Results: Ciliary body involvement was evident in all cases. All 4 patients had received radiation doses of 400 Gy or more to the tumor base. The mean time interval between plaque radiotherapy and scleral necrosis was 24.5 ± 7.5 months (range, 18-34 months). Successful results were achieved in all patients with tectonic graft. No patients experienced graft thinning, rejection, infection, or tumor recurrence in a mean follow-up of 28.5 ± 7.9 months (range, 20-39 months). Conclusions: Corneal patch graft by anterior corneal button from Descemet stripping automated endothelial keratoplasty donor tissue results in successful restoration of globe integrity and satisfactory cosmetic appearance in patients with scleral necrosis secondary to plaque radiotherapy. © 2016 Wolters Kluwer Health, Inc. All rights reserved.