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Ameliorative Effects of Akkermansia Muciniphila on Anxiety-Like Behavior and Cognitive Deficits in a Rat Model of Alzheimer's Disease Publisher Pubmed



Maftoon H1 ; Davar Siadat S2, 3 ; Tarashi S2, 3 ; Soroush E2 ; Basir Asefi M4 ; Rahimi Foroushani A5 ; Mehdi Soltan Dallal M1, 6
Authors
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Authors Affiliations
  1. 1. Department of pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran
  3. 3. Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Food Microbiology Research Centre, Tehran University of Medical Sciences, Tehran, Iran

Source: Brain Research Published:2024


Abstract

Alzheimer's Disease (AD) is the primary neurodegenerative disorder in the elderly, lacking a definitive treatment. The gut microbiota influences the gut-brain axis by aiding in hypothalamic–pituitary–adrenal (HPA) axis development and neuromodulator production. Research links AD and gut microbiota, suggesting gut microbiota regulation could be a therapeutic approach for AD. This study explores Akkermansia muciniphila's impact on preventing AD. This research investigates the effect of A. muciniphila consumption (1 × 109 CFU) on tau protein-induced AD rats compared to a control group. Rats were divided into four groups: sham, sham + Akk, AD (tau-induced rats), and AD + Akk (tau-induced rats treated with A. muciniphila). A. muciniphila gavage lasted five weeks. Rats underwent qRT-PCR analysis to assess mRNA expression of pro-inflammatory factors (TNF-α, IL-6, IL-1β, IFN-γ) in the hippocampus. Behavioral tests included Morris Water Maze (MWM), Passive Avoidance Memory Test (Shuttle box), Elevated Plus Maze (EPM), and marble burying. After five weeks of A. muciniphila treatment, anxiety-like behavior significantly decreased. The AD group receiving A. muciniphila showed improved spatial and recognition memory compared to the AD group. Pro-inflammatory cytokine levels (TNF-α, IL-1β, IL-6, IFN-γ) decreased. A. muciniphila effectively reduces cognitive impairments and anxiety-related behavior, showing promise as an AD therapeutic by influencing the gut-brain axis. © 2024 Elsevier B.V.
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