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Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review Publisher Pubmed



Sadatshirazi MS1 ; Sadeghiadl M1 ; Akbarabadi A1 ; Ashabi G2 ; Mokri A1, 3 ; Zarrindast MR1, 4, 5, 6
Authors
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Authors Affiliations
  1. 1. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  6. 6. Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran

Source: CNS and Neurological Disorders - Drug Targets Published:2023


Abstract

Drug addiction is a chronic relapsing disorder that makes it a global problem. Genetics and environmental factors are the two most important factors that make someone vulnerable to drug addic-tion. Investigations in the past decade highlighted the role of epigenetics in the inter/transgenerational inheritance of drug addiction. A growing body of evidence showed that parental (paternal, maternal, and biparental) drug exposure before conception changes the phenotype of the offspring, which is cor-related with neurochemical and neurostructural changes in the brain. The current paper reviews the effects of parental (maternal, paternal, and biparental) exposure to drugs of abuse (opioids, cocaine, nic-otine, alcohol, and cannabis) before gestation in animal models. © 2023 Bentham Science Publishers.
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