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Molecular Characterization of Hepatitis D Virus Genotypes Circulating in Iran Publisher



Meysami P1 ; Alavian SM2 ; Monavari SH3 ; Mozhgani SH1, 4 ; Taghizadeh M5 ; Farahani M6 ; Ansari N1 ; Keyvani H3
Authors

Source: Future Virology Published:2018


Abstract

Aim: To determine the molecular epidemiology and characterization of hepatitis D virus (HDV) genotypes circulating in different provinces of Iran. Patients & methods: In this study, the presence of HDV RNA was tested in sera that were positive for hepatitis B surface antigen and HDV antibody by nested-PCR. HDV genotypes were subsequently analyzed using restriction fragment length polymorphism (RFLP) assay and then confirmed by sequencing. Results: 86.5% of positive PCR patients had genotype I and 8.1% had genotype II while the genotype of 5.4% of the patients remained undetermined by RFLP. Sequencing followed by phylogenetic analysis demonstrated that all the Iranian isolates were from genotype I. Conclusion: Although analyzing the RFLP of RT-PCR is a simpler method, the gold standard of genotyping of HDV is the phylogenetic analysis based on sequencing. © 2018 Future Medicine Ltd.
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