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Occult Hcv and Occult Hbv Coinfection in Iranian Human Immunodeficiency Virus-Infected Individuals Publisher Pubmed



Jamshidi S1 ; Bokharaeisalim F1 ; Esghaei M1 ; Bastani MN1 ; Garshasbi S2 ; Chavoshpour S3 ; Dehghanidehej F2 ; Fakhim S4 ; Khanaliha K5
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Vice Chancellor for Health, Iran University of Medical Sciences (IUMS), Tehran, Iran
  3. 3. Department of Virology, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  4. 4. Department of Civil Engineering, Faculty of Engineering, Payame Noor University, Karaj, Iran
  5. 5. Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Medical Virology Published:2020


Abstract

The presence of hepatitis C virus (HCV) genome in liver biopsy or peripheral blood mononuclear cell (PBMC) specimens in the absence of detectable HCV-RNA in plasma of the people with or without anti-HCV antibodies has defined as occult HCV infection (OCI), whereas occult hepatitis B virus infection (OBI) is detection of hepatitis B virus (HBV) genome in the absence of traceable hepatitis B surface antigen in the plasma samples of patients. The purpose of this study is to determine the presence of OBI and OCI in human immunodeficiency virus (HIV)-infected individuals. In this cross-sectional research, 190 Iranian HIV-infected individuals were enrolled from September 2015 to February 2019. All participants were tested regarding various serological markers for HCV and HBV infections. Viral RNA and DNA were extracted from plasma and PBMC specimens, and the presence of HCV-RNA in plasma and PBMC samples was tested using reverse transcriptase-nested polymerase chain reaction (PCR), HBV viral load was determined in plasma samples using COBAS TaqMan 48 Kit, and also the presence of the HBV-DNA in PBMC samples was tested by real-time PCR. In this study, the prevalence of OBI and OCI in HIV-infected individuals was 3.1% and 11.4%, respectively. The genotypes of HCV in the patients with OCI were as follows: 57.1% were infected with subtype 3a, 35.7% were infected with subtype 1a, and 7.1% was infected with subtype 1b. It is noteworthy that in this study, two patients (1.1%) had OCI/OBI coinfections. The present study revealed that 1.1% of Iranian HIV-infected individuals had OBI and OCI at the same time. Therefore, it seems that designing prospective surveys to determine the presence of this coinfection in HIV-infected individuals is informative. © 2020 Wiley Periodicals, Inc.
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