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Correlation Between Low-Dose Chest Computed Tomography and Rt-Pcr Results for the Diagnosis of Covid-19: A Report of 27,824 Cases in Tehran, Iran Publisher Pubmed



Zali A1 ; Sohrabi MR2, 3 ; Mahdavi A4 ; Khalili N5 ; Taheri MS6 ; Maher A7 ; Sadoughi M8 ; Zarghi A9 ; Ziai SA10 ; Shabestari AA11 ; Bakhshayeshkaram M12 ; Haghighatkhah H13 ; Salevatipour B14 ; Abrishami A16 Show All Authors
Authors
  1. Zali A1
  2. Sohrabi MR2, 3
  3. Mahdavi A4
  4. Khalili N5
  5. Taheri MS6
  6. Maher A7
  7. Sadoughi M8
  8. Zarghi A9
  9. Ziai SA10
  10. Shabestari AA11
  11. Bakhshayeshkaram M12
  12. Haghighatkhah H13
  13. Salevatipour B14
  14. Abrishami A16
  15. Raoufi M17
  16. Dehghan P18
  17. Bagheri AK19
  18. Khoshnoud RJ20
  19. Hanani K21
Show Affiliations
Authors Affiliations
  1. 1. Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Community Medicine Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Shahid Beheshti University of Medical Sciences, Radiology Department, Imam Hossein Hospital, Tehran, Iran
  5. 5. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Radiology Department, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran
  7. 7. School of Management and Medical Education, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  11. 11. Department of Radiology, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  13. 13. Department of Diagnostic Imaging, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran
  14. 14. Department of Diagnostic Imaging, Loghman Hakim Hospital
  15. 15. Shahid Behesti University of Medical Sciences, Tehran, Iran
  16. 16. Department of Radiology, Shahid Labbafinejad hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  17. 17. Department of Radiology, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences
  18. 18. Imaging Department, Taleghani Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran
  19. 19. Shahid Beheshti University of Medical Sciences, Shohadaye Tajrish Hospital, Tehran, Iran
  20. 20. Department of Neurosurgery, Shahid Beheshti University of Medical Science, Tehran, Iran
  21. 21. School of Statistics & Information Technology Management, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Academic Radiology Published:2021


Abstract

Rationale and Objectives: Real-time polymerase chain reaction (RT-PCR) remains the gold standard for confirmation of Coronavirus Disease 2019 (COVID-19) despite having many disadvantages. Here, we investigated the diagnostic performance of chest computed tomography (CT) as an alternative to RT-PCR in patients with clinical suspicion of COVID-19 infection. Methods: In this descriptive cross-sectional study, 27,824 patients with clinical suspicion of COVID-19 infection who underwent unenhanced low-dose chest CT from 20 February, 2020 to 21 May, 2020 were evaluated. Patients were recruited from seven specifically designated hospitals for patients with COVID-19 infection affiliated to Shahid Beheshti University of Medical Sciences. In each hospital, images were interpreted by two independent radiologists. CT findings were considered as positive/negative for COVID-19 infection based on RSNA diagnostic criteria. Then, the correlation between the number of daily positive chest CT scans and number of daily PCR-confirmed cases and COVID-19-related deaths in Tehran province during this three-month period was assessed. The trends of admission rate and patients with positive CT scans were also evaluated. Results: A strong positive correlation between the numbers of daily positive CT scans and daily PCR-confirmed COVID-19 cases (r = 0.913, p < 0.001) was observed. Furthermore, in hospitals located in regions with a lower socioeconomic status, the admission rate and number of positive cases within this three-month period was higher as compared to other hospitals. Conclusion: Low-dose chest CT is a safe, rapid and reliable alternative to RT-PCR for the diagnosis of COVID-19 in high-prevalence regions. In addition, our study provides further evidence for considering patients’ socioeconomic status as an important risk factor for COVID-19. © 2020 The Association of University Radiologists
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