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A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation Publisher Pubmed



Berney T1 ; Andres A1 ; Bellin MD2 ; De Koning EJP3 ; Johnson PRV4 ; Kay TWH5 ; Lundgren T6 ; Rickels MR7 ; Scholz H8 ; Stock PG9 ; White S10 ; Aghayan HR11 ; Alejandro R12 ; Ricordi C12 Show All Authors
Authors
  1. Berney T1
  2. Andres A1
  3. Bellin MD2
  4. De Koning EJP3
  5. Johnson PRV4
  6. Kay TWH5
  7. Lundgren T6
  8. Rickels MR7
  9. Scholz H8
  10. Stock PG9
  11. White S10
  12. Aghayan HR11
  13. Alejandro R12
  14. Ricordi C12
  15. Anazawa T13
  16. Armanet M14
  17. Cattan P14
  18. Badet L15
  19. Buron F15
  20. Balamurugan AN16
  21. Mokshagundam SPL16
  22. Barton FB17
  23. Benhamou PY18
  24. Lablanche S18
  25. Berishvili E19
  26. Bosco D19
  27. Pernin N19
  28. Wassmer CH19
  29. Bertuzzi F20
  30. Borot S21
  31. Bottino R22
  32. Brendel MD23
  33. Caicedo LA24
  34. Echeverri GJ24
  35. Casey J25
  36. Choudhary P26
  37. Coates PT27
  38. Conget I28
  39. Venturaaguiar P28
  40. Cooper M29
  41. Khan KM29
  42. Debskaslizien A30
  43. Golebiewska J30
  44. Desai CS31
  45. Dominguezgil B32, 62
  46. Drago J33
  47. Hyon SH33
  48. Fedaruk D34
  49. Goss JA35
  50. Hering BJ36
  51. Jung HS37
  52. Kanak MA38
  53. Kandeel F39
  54. Kenmochi T40
  55. Kessler L41
  56. Munch M41
  57. Keymeulen B42
  58. Khambalia H43
  59. Kim JH44
  60. Korsgren O45
  61. Kudva YC46
  62. Stegall MD46
  63. Labriola L47
  64. Lee EY48
  65. Yoon KH48
  66. Lehmann R49
  67. Ludwig B50
  68. Lundren T51
  69. Luo X52
  70. Maffi P53
  71. Piemonti L53
  72. Markmann J54
  73. Mattina A55
  74. Meloche M56
  75. Morgan K57
  76. Naziruddin B58
  77. Onaca N58
  78. Odorico JS59
  79. Paraskevas S60
  80. Pattou F61
  81. Vantyghem MC61
  82. Romo RM32, 62
  83. Saudek F63
  84. Shapiro JAM64
  85. Shaw J65
  86. Shimoda M66
  87. Webster A67
  88. Witkowski P68
  89. Wojtusciszyn A69
  90. Wszola M70
Show Affiliations
Authors Affiliations
  1. 1. Division of Transplantation, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland
  2. 2. Departments of Pediatrics and Surgery, University of Minnesota Medical Center, Minneapolis, MN, United States
  3. 3. Department of Medicine, Leiden University Medical Center, Leiden, Netherlands
  4. 4. Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
  5. 5. Department of Medicine, St. Vincent’s Hospital, St. Vincent’s Institute of Medical Research, University of Melbourne, Melbourne, VIC, Australia
  6. 6. Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden
  7. 7. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States
  8. 8. Department of Transplant Medicine, Institute for Surgical Research, Oslo University Hospital, Oslo, Norway
  9. 9. Division of Transplantation, Department of Surgery, University of California at San Francisco, San Francisco, CA, United States
  10. 10. Department of HPB and Transplant Surgery, The Freeman Hospital, Newcastle Upon Tyne, United Kingdom
  11. 11. Tehran University of Medical Sciences, Tehran, Iran
  12. 12. University of Miami, Miami, FL, United States
  13. 13. Kyoto University, Kyoto, Japan
  14. 14. Hopital Saint-Louis, Paris, France
  15. 15. Hospices Civils de Lyon, Lyon, France
  16. 16. University of Louisville, Louisville, KY, United States
  17. 17. Collaborative Islet transplant Registry, Rockville, MD, United States
  18. 18. Grenoble-Alpes University, Grenoble, France
  19. 19. University of Geneva, Geneva, Switzerland
  20. 20. Niguarda Hospital, Milan, Italy
  21. 21. Universite de Franche-Comte, Besancon, France
  22. 22. University of Pittsburgh, Pittsburgh, PA, United States
  23. 23. Justus-Liebig University, Giessen, Germany
  24. 24. Fundacion Valle Del Lili, Cali, Colombia
  25. 25. Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
  26. 26. King’s College, London, United Kingdom
  27. 27. Royal Adelaide Hospital, Adelaide, Australia
  28. 28. Hospital Clinic, Barcelona, Spain
  29. 29. Medstar Georgetown Transplant Institute, Washington, DC, United States
  30. 30. Medical University of Gdansk, Gdansk, Poland
  31. 31. University of North Carolina, Chapel Hill, NC, United States
  32. 32. Organizacion Nacional de Trasplantes, Madrid, Spain
  33. 33. Hospital Italiano, Buenos Aires, Argentina
  34. 34. Republican Center for Organ and Tissue Transplantation, Minsk, Belarus
  35. 35. Baylor College of Medicine, Houston, TX, United States
  36. 36. University of Minnesota, Minneapolis, MN, United States
  37. 37. Seoul National University Hospital, Seoul, South Korea
  38. 38. Virginia Commonwealth University, Richmond, VA, United States
  39. 39. City of Hope Medical Center, Duarte, CA, United States
  40. 40. Japan Islet Transplant Registry, Toyoake, Japan
  41. 41. Strasbourg University, Strasbourg, France
  42. 42. Brussels Free University, Brussels, Belgium
  43. 43. University of Manchester, Manchester, United Kingdom
  44. 44. Samsung Medical Center, Seoul, South Korea
  45. 45. University of Uppsala, Uppsala, Sweden
  46. 46. Mayo Clinic, Rochester, MN, United States
  47. 47. University of Sao Paulo, Sao Paulo, Brazil
  48. 48. Seoul Catholic University, Seoul, South Korea
  49. 49. University of Zurich, Zurich, Switzerland
  50. 50. Technische Universitat Dresden, Dresden, Germany
  51. 51. Karolinska Institute, Stockholm, Sweden
  52. 52. Northwestern University, Chicago, IL, United States
  53. 53. San Raffaele Institute, Milan, Italy
  54. 54. Harvard University, Boston, MA, United States
  55. 55. IRCCS ISMETT - UPMC Italy, Palermo, Italy
  56. 56. University of British Columbia, Vancouver, Canada
  57. 57. Medical University of South Carolina, Charleston, SC, United States
  58. 58. Baylor Simmons Transplant Institute, Dallas, TX, United States
  59. 59. University of Wisconsin, Madison, WI, United States
  60. 60. McGill University, Montreal, Canada
  61. 61. Lille University, Lille, France
  62. 62. Organizacion Nacional de Trasplantes, Madrid, Spain
  63. 63. Institute for Clinical and Experimental Medicine, Prague, Czech Republic
  64. 64. University of Alberta, Edmonton, Canada
  65. 65. Freeman Hospital, Newcastle-upon-Tyne, United Kingdom
  66. 66. National Center for Global Health and Medicine, Tokyo, Japan
  67. 67. University of Sydney, Sydney, Australia
  68. 68. University of Chicago, Chicago, IL, United States
  69. 69. Montpellier University, Montpellier, France
  70. 70. Foundation of Research and Science Development, Warsaw, Poland

Source: Transplant International Published:2022


Abstract

A global online survey was administered to 69 islet transplantation programs, covering 84 centers and 5 networks. The survey addressed questions on program organization and activity in the 2000–2020 period, including impact on activity of national health care coverage policies. We obtained full data from 55 institutions or networks worldwide and basic activity data from 6 centers. Additional data were obtained from alternative sources. A total of 94 institutions and 5 networks was identified as having performed islet allotransplantation. 4,365 islet allotransplants (2,608 in Europe, 1,475 in North America, 135 in Asia, 119 in Oceania, 28 in South America) were reported in 2,170 patients in the survey period. From 15 centers active at the start of the study period, the number of simultaneously active islet centers peaked at 54, to progressively decrease to 26 having performed islet allotransplants in 2020. Notably, only 16 centers/networks have done >100 islet allotransplants in the survey period. Types of transplants performed differed notably between North America and the rest of the world, in particular with respect to the near-absence of simultaneous islet-kidney transplantation. Absence of heath care coverage has significantly hampered transplant activity in the past years and the COVID-19 pandemic in 2020. Copyright © 2022 Berney, Andres, Bellin, de Koning, Johnson, Kay, Lundgren, Rickels, Scholz, Stock, White and the International Islet Transplant Centers.