Therapy of Endocrine Disease: Islet Transplantation for Type 1 Diabetes: So Close and yet so Far Away

Therapy of Endocrine Disease: Islet Transplantation for Type 1 Diabetes: So Close and yet so Far Away Publisher Pubmed

Khosravimaharlooei M^{1, 7} ; Hajizadehsaffar E¹ ; Tahamtani Y¹ ; Basiri M¹ ; Montazeri L¹ ; Khalooghi K¹ ; Ashtiani MK¹ ; Farrokhi A^{1, 7} ; Aghdami N² ; Hashemi Nejad AS¹ ; Larijani MB³ ; De Leu N⁴ ; Heimberg H⁴ ; Luo X⁵ Show All Authors

Khosravimaharlooei M^{1, 7}
Hajizadehsaffar E¹
Tahamtani Y¹
Basiri M¹
Montazeri L¹
Khalooghi K¹
Ashtiani MK¹
Farrokhi A^{1, 7}
Aghdami N²
Hashemi Nejad AS¹
Larijani MB³
De Leu N⁴
Heimberg H⁴
Luo X⁵
Baharvand H^{1, 6}

Show Affiliations

1. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Tehran, Iran
2. Department of Regenerative Medicine at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
3. Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium
5. Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
6. Department of Developmental Biology, University of Science and Culture, ACECR, Tehran, 148-16635, Iran
7. Department of Surgery, University of British Columbia, Vancouver, BC, Canada

Source: European Journal of Endocrinology Published:2015

Abstract

Over the past decades, tremendous efforts have been made to establish pancreatic islet transplantation as a standard therapy for type 1 diabetes. Recent advances in islet transplantation have resulted in steady improvements in the 5-year insulin independence rates for diabetic patients. Here we review the key challenges encountered in the islet transplantation field which include islet source limitation, sub-optimal engraftment of islets, lack of oxygen and blood supply for transplanted islets, and immune rejection of islets. Additionally, we discuss possible solutions for these challenges. © 2015 European Society of Endocrinology.

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Style	Citing Format
MLA	Khosravimaharlooei M, et al.. "Therapy of Endocrine Disease: Islet Transplantation for Type 1 Diabetes: So Close and yet so Far Away." European Journal of Endocrinology, vol. 173, no. 5, 2015, pp. R165-R183.
APA	Khosravimaharlooei M, Hajizadehsaffar E, Tahamtani Y, Basiri M, Montazeri L, Khalooghi K, Ashtiani MK, Farrokhi A, Aghdami N, Hashemi Nejad AS, Larijani MB, De Leu N, Heimberg H, Luo X, Baharvand H (2015). Therapy of Endocrine Disease: Islet Transplantation for Type 1 Diabetes: So Close and yet so Far Away. European Journal of Endocrinology, 173(5), R165-R183.
Chicago	Khosravimaharlooei M, Hajizadehsaffar E, Tahamtani Y, Basiri M, Montazeri L, Khalooghi K, Ashtiani MK, et al.. "Therapy of Endocrine Disease: Islet Transplantation for Type 1 Diabetes: So Close and yet so Far Away." European Journal of Endocrinology 173, no. 5 (2015): R165-R183.
Harvard	Khosravimaharlooei M et al. (2015) 'Therapy of Endocrine Disease: Islet Transplantation for Type 1 Diabetes: So Close and yet so Far Away', European Journal of Endocrinology, 173(5), pp. R165-R183.
Vancouver	Khosravimaharlooei M, Hajizadehsaffar E, Tahamtani Y, Basiri M, Montazeri L, Khalooghi K, et al.. Therapy of Endocrine Disease: Islet Transplantation for Type 1 Diabetes: So Close and yet so Far Away. European Journal of Endocrinology. 2015;173(5):R165-R183.
BibTex	@article{ author = {Khosravimaharlooei M and Hajizadehsaffar E and Tahamtani Y and Basiri M and Montazeri L and Khalooghi K and Ashtiani MK and Farrokhi A and Aghdami N and Hashemi Nejad AS and Larijani MB and De Leu N and Heimberg H and Luo X and Baharvand H}, title = {Therapy of Endocrine Disease: Islet Transplantation for Type 1 Diabetes: So Close and yet so Far Away}, journal = {European Journal of Endocrinology}, volume = {173}, number = {5}, pages = {R165-R183}, year = {2015} }
RIS	TY - JOUR AU - Khosravimaharlooei M AU - Hajizadehsaffar E AU - Tahamtani Y AU - Basiri M AU - Montazeri L AU - Khalooghi K AU - Ashtiani MK AU - Farrokhi A AU - Aghdami N AU - Hashemi Nejad AS AU - Larijani MB AU - De Leu N AU - Heimberg H AU - Luo X AU - Baharvand H TI - Therapy of Endocrine Disease: Islet Transplantation for Type 1 Diabetes: So Close and yet so Far Away JO - European Journal of Endocrinology VL - 173 IS - 5 SP - R165 EP - R183 PY - 2015 ER -

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