An Early Diagnosed Medulloblastoma of the Vermis Publisher



Parvaresh M¹ ; Ghadirian H² ; Fattahi A¹ ; Sadeghipour A³ Show Affiliations
Source: Oncology in Clinical Practice Published:2025

Abstract

Medulloblastoma is categorized into different histological and molecular subtypes with unique characteristics that make diagnosis challenging. We present a case of a 30-year-old male with continuous nausea and vomiting for 3 months ago. Imaging revealed a brief signal change in the vermis. He had normal results of neurologic examinations. The lesion was completely removed surgically. The histopathology exam revealed classic medulloblastoma, non-SHH, and non-WNT, and the patient was referred for adjuvant therapy. In this case, the low intensity of changes confined to the vermis, without edema and gadolinium enhancement ruled out medulloblastoma. The WNT was a more probable subtype, but histopathology ruled that out. It seems that the decision to operate on this patient was the best approach because this surgery sped up the diagnosis and his chemoradiotherapy started sooner. In conclusion, in the case of lesions in the posterior fossa, medulloblastoma should always be kept in mind because an early diagnosis can improve the prognosis. Copyright © 2025 Via Medica.