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Application of Radiomics for Diagnosis, Subtyping, and Prognostication of Medulloblastomas: A Systematic Review Publisher Pubmed



Fotouhi M1 ; Shahbandi A2 ; Mehr FSK3 ; Shahla MM4 ; Nouredini SM5 ; Kankam SB6, 7 ; Khorasanizadeh M8 ; Chambless LB9
Authors
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Authors Affiliations
  1. 1. Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medical Physics and Engineering Department, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  5. 5. Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  6. 6. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, United States
  7. 7. T. H. Chan School of Public Health, Harvard University, Cambridge, MA, United States
  8. 8. Department of Neurosurgery, Mount Sinai Hospital, Icahn School of Medicine, New York, NY, United States
  9. 9. Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, United States

Source: Neurosurgical Review Published:2024


Abstract

Applications of radiomics for clinical management of medulloblastomas are expanding. This systematic review aims to aggregate and overview the current role of radiomics in the diagnosis, subtyping, and prognostication of medulloblastomas. The present systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed/MEDLINE were searched using a standardized search term. Articles found within the database from the inception until November 2022 were considered for screening. Retrieved records were screened independently by two authors based on their titles and abstracts. The full text of selected articles was reviewed to finalize the eligibility. Due to the heterogeneity of included studies, no formal data synthesis was conducted. Of the 249 screened citations, 21 studies were included and analyzed. Radiomics demonstrated promising performance for discriminating medulloblastomas from other posterior fossa tumors, particularly ependymomas and pilocytic astrocytomas. It was also efficacious in determining the subtype (i.e., WNT+, SHH+, group 3, and group 4) of medulloblastomas non-invasively. Regarding prognostication, radiomics exhibited some ability to predict overall survival and progression-free survival of patients with medulloblastomas. Our systematic review revealed that radiomics represents a promising tool for diagnosis and prognostication of medulloblastomas. Further prospective research measuring the clinical value of radiomics in this setting is warranted. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
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