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Pei-Based Functional Materials: Fabrication Techniques, Properties, and Biomedical Applications Publisher Pubmed



Fattahi N1, 2 ; Gorgannezhad L3 ; Masoule SF1 ; Babanejad N4 ; Ramazani A2 ; Raoufi M5 ; Sharifikolouei E6 ; Foroumadi A1, 7 ; Khoobi M1, 8
Authors
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Authors Affiliations
  1. 1. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  2. 2. Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, 45371-38791, Iran
  3. 3. Queensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, 170 Kessels Road, Brisbane, 4111, QLD, Australia
  4. 4. College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, United States
  5. 5. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 13169-43551, Iran
  6. 6. Department of Applied Science and Technology, Politecnico di Torino, Corso Duca Degli Abruzzi 24, Turin (TO), 10129, Italy
  7. 7. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
  8. 8. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Advances in Colloid and Interface Science Published:2024


Abstract

Cationic polymers have recently attracted considerable interest as research breakthroughs for various industrial and biomedical applications. They are particularly interesting due to their highly positive charges, acceptable physicochemical properties, and ability to undergo further modifications, making them attractive candidates for biomedical applications. Polyethyleneimines (PEIs), as the most extensively utilized polymers, are one of the valuable and prominent classes of polycations. Owing to their flexible polymeric chains, broad molecular weight (MW) distribution, and repetitive structural units, their customization for functional composites is more feasible. The specific beneficial attributes of PEIs could be introduced by purposeful functionalization or modification, long service life, biocompatibility, and distinct geometry. Therefore, PEIs have significant potential in biotechnology, medicine, and bioscience. In this review, we present the advances in PEI-based nanomaterials, their transfection efficiency, and their toxicity over the past few years. Furthermore, the potential and suitability of PEIs for various applications are highlighted and discussed in detail. This review aims to inspire readers to investigate innovative approaches for the design and development of next-generation PEI-based nanomaterials possessing cutting-edge functionalities and appealing characteristics. © 2024 Elsevier B.V.