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Ph-Responsive Polymer in a Core–Shell Magnetic Structure As an Efficient Carrier for Delivery of Doxorubicin to Tumor Cells Publisher



Zaaeri F1 ; Khoobi M2, 3 ; Rouini M1 ; Akbari Javar H1, 2
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2018


Abstract

A pH-responsive polymer derived from polyethyleneimine with zwitterionic function was used as a shell around super paramagnetic iron oxide nanoparticles (SPIONs), to introduce an efficient drug carrier for cancer drug delivery and imaging. Core–shell magnetic Fe3O4@FA-PEI-SUC (SUC: Succinate conjugated) nanoparticles were attained and characterized. Right chemical attachments, 61.34% modification of primary amino groups of poly(ethyleneimine) (PEI) in PEI–SUC, spherical shape, core–shell structure, crystal structure of SPIONs, 18.23% polymer coating of NPs, 8% decrease in magnetization following polymer coating around SPIONs, doxorubicin loading efficiency 85.19%, two times more released amount in acidic pH, and proper toxicity results were obtained by different analysis methods. © 2017, © 2017 Taylor & Francis.
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