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Evaluating the Efficacy of Tissue-Engineered Human Amniotic Membrane in the Treatment of Myocardial Infarction Publisher Pubmed



Khorramirouz R1 ; Kameli SM1 ; Fendereski K1 ; Daryabari SS1 ; Kajbafzadeh AM1
Authors

Source: Regenerative Medicine Published:2019


Abstract

Aim: The aim of this study was to evaluate the efficacy of tissue-engineered amniotic membrane (AM) in the treatment of myocardial infarction lesions. Materials & methods: 20 rats were subjected to coronary arterial ligation in order to induce myocardial infarction injury. Decellularized human AMs were seeded with 2 × 105 adipose-derived mesenchymal stem cells and were implanted in the infarcted hearts. Results & conclusion: Histological and immunohistochemical evaluations indicated the regeneration of cardiomyocytes and reduction of inflammation and fibrosis in the patch-implanted group compared with a control group, 14 days after the surgery. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate biotin nick-end labeling assay was suggestive for apoptosis reduction in the patch-implanted specimens. This study suggested that human AM can be developed into a novel treatment for treating postmyocardial infarction. © 2019 Future Medicine Ltd.
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