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Evaluating the Efficacy of Tissue-Engineered Human Amniotic Membrane in the Treatment of Myocardial Infarction Publisher Pubmed



Khorramirouz R1 ; Kameli SM1 ; Fendereski K1 ; Daryabari SS1 ; Kajbafzadeh AM1
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Authors Affiliations
  1. 1. Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Pediatric Center of Excellence, Tehran University of Medical Sciences, Children's Hospital Medical Center, Tehran, 1419433151, Iran

Source: Regenerative Medicine Published:2019


Abstract

Aim: The aim of this study was to evaluate the efficacy of tissue-engineered amniotic membrane (AM) in the treatment of myocardial infarction lesions. Materials & methods: 20 rats were subjected to coronary arterial ligation in order to induce myocardial infarction injury. Decellularized human AMs were seeded with 2 × 105 adipose-derived mesenchymal stem cells and were implanted in the infarcted hearts. Results & conclusion: Histological and immunohistochemical evaluations indicated the regeneration of cardiomyocytes and reduction of inflammation and fibrosis in the patch-implanted group compared with a control group, 14 days after the surgery. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate biotin nick-end labeling assay was suggestive for apoptosis reduction in the patch-implanted specimens. This study suggested that human AM can be developed into a novel treatment for treating postmyocardial infarction. © 2019 Future Medicine Ltd.
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