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T Helper Type (Th1/Th2) Responses to Sars-Cov-2 and Influenza a (H1n1) Virus: From Cytokines Produced to Immune Responses Publisher Pubmed



Aleebrahimdehkordi E1, 2 ; Molavi B3 ; Mokhtari M4 ; Deravi N1, 5 ; Fathi M5 ; Fazel T6 ; Mohebalizadeh M1, 7 ; Koochaki P8 ; Shobeiri P9, 10, 11, 12 ; Hasanpourdehkordi A13
Authors
Show Affiliations
Authors Affiliations
  1. 1. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  2. 2. Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  3. 3. Department of Anesthesiology, Faculty of Paramedical, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Dental Faculty, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. school of international campus, Guilan University of Medical Sciences, Rasht, Iran
  7. 7. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
  8. 8. Islamic Azad University, Tehran Medical Science Branch, faculty of medicine, Tehran, Iran
  9. 9. School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  10. 10. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  11. 11. Non–Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  13. 13. Social Determinants of Health Research Center, School of Allied Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Transplant Immunology Published:2022


Abstract

Cytokines produced by T helper cells (Th cells) have essential roles in the body's defense against viruses. Type 1 T helper (Th1) cells are essential for the host defense toward intracellular pathogens while T helper type 2 (Th2) cells are considered to be critical for the helminthic parasites' elimination swine-origin influenza A (H1N1) virus, a disease led to an epidemic in 2009 and rapidly spread globally via human-to-human transmission. Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic in 2020 and is a serious threat to the public health. Pulmonary immunopathology is the leading cause of death during influenza and SARS-CoV-2 epidemics and pandemics. Influenza and SARS-CoV-2 cause high levels of cytokines in the lung. Both inadequate levels and high levels of specific cytokines can have side effects. In this literature review article, we want to compare the Th1 and Th2 cells responses in SARS-CoV-2 and H1N1. © 2021
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