Granulocyte-Colony Stimulating Factor (G-Csf): An Emerging Therapeutic Approach for Amyotrophic Lateral Sclerosis (Als)

Granulocyte-Colony Stimulating Factor (G-Csf): An Emerging Therapeutic Approach for Amyotrophic Lateral Sclerosis (Als) Publisher Pubmed

Vafaei Mastanabad M¹ ; Nooraei A² ; Hassan Zadeh Tabatabaei MS³ ; Akbari Fakhrabadi A⁴ ; Jafarzadeh F⁵

Show Affiliations

1. Medical Doctor of Saveh Healthcare Network, Saveh, Iran
2. Comparative Anatomy and Embryology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Research Committee, Medical School, Arak University of Medical Sciences, Arak, Iran
5. Department of Internal Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnourd, Iran

Source: Acta Neurologica Belgica Published:2023

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by neuronal degeneration and inflammation in the nerves. G-CSF is a 19.6-kDa hematopoietic growth factor which is essential for the proliferation and differentiation of granulocyte hematopoietic progenitors. G-CSF exerts neuroprotective activities by induction of neuronal regeneration, inhibition of neuronal apoptosis, mobilization of Hematopoietic stem cells (HSCs), regulation of pro and anti-inflammatory cytokines, and activation of angiogenesis. Pre-clinical studies have shown significant efficacy of G-CSF therapy in mSOD1G93A mice models. G-CSF treatments were able to increase the survival of mice. However, clinical studies on ALS patients failed to clone pre-clinical results. Considering the potential role of G-CSF in nervous system regeneration, this study aimed to comprehensively review the clinical and pre-clinical studies addressing G-CSF in ALS treatment. © 2022, The Author(s) under exclusive licence to Belgian Neurological Society.

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Style	Citing Format
MLA	Vafaei Mastanabad M, et al.. "Granulocyte-Colony Stimulating Factor (G-Csf): An Emerging Therapeutic Approach for Amyotrophic Lateral Sclerosis (Als)." Acta Neurologica Belgica, vol. 123, no. 3, 2023, pp. 763-771.
APA	Vafaei Mastanabad M, Nooraei A, Hassan Zadeh Tabatabaei MS, Akbari Fakhrabadi A, Jafarzadeh F (2023). Granulocyte-Colony Stimulating Factor (G-Csf): An Emerging Therapeutic Approach for Amyotrophic Lateral Sclerosis (Als). Acta Neurologica Belgica, 123(3), 763-771.
Chicago	Vafaei Mastanabad M, Nooraei A, Hassan Zadeh Tabatabaei MS, Akbari Fakhrabadi A, Jafarzadeh F. "Granulocyte-Colony Stimulating Factor (G-Csf): An Emerging Therapeutic Approach for Amyotrophic Lateral Sclerosis (Als)." Acta Neurologica Belgica 123, no. 3 (2023): 763-771.
Harvard	Vafaei Mastanabad M et al. (2023) 'Granulocyte-Colony Stimulating Factor (G-Csf): An Emerging Therapeutic Approach for Amyotrophic Lateral Sclerosis (Als)', Acta Neurologica Belgica, 123(3), pp. 763-771.
Vancouver	Vafaei Mastanabad M, Nooraei A, Hassan Zadeh Tabatabaei MS, Akbari Fakhrabadi A, Jafarzadeh F. Granulocyte-Colony Stimulating Factor (G-Csf): An Emerging Therapeutic Approach for Amyotrophic Lateral Sclerosis (Als). Acta Neurologica Belgica. 2023;123(3):763-771.
BibTex	@article{ author = {Vafaei Mastanabad M and Nooraei A and Hassan Zadeh Tabatabaei MS and Akbari Fakhrabadi A and Jafarzadeh F}, title = {Granulocyte-Colony Stimulating Factor (G-Csf): An Emerging Therapeutic Approach for Amyotrophic Lateral Sclerosis (Als)}, journal = {Acta Neurologica Belgica}, volume = {123}, number = {3}, pages = {763-771}, year = {2023} }
RIS	TY - JOUR AU - Vafaei Mastanabad M AU - Nooraei A AU - Hassan Zadeh Tabatabaei MS AU - Akbari Fakhrabadi A AU - Jafarzadeh F TI - Granulocyte-Colony Stimulating Factor (G-Csf): An Emerging Therapeutic Approach for Amyotrophic Lateral Sclerosis (Als) JO - Acta Neurologica Belgica VL - 123 IS - 3 SP - 763 EP - 771 PY - 2023 ER -

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