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Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis Publisher Pubmed



Hajivalili M1, 2 ; Pourgholi F1, 2 ; Kafil HS3 ; Jadidiniaragh F1, 2, 4 ; Yousefi M1, 2, 3
Authors
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Authors Affiliations
  1. 1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Immunology, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Stem Cell Research and Therapy Published:2016


Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder which is characterized by motor neuron (MN) dysfunction, progressive paralysis, and death. Although several therapeutic approaches have been used for treatment of ALS, little success has been achieved. Natural vectors such as mesenchymal stem cells (MSCs) can be a promising tool for overcoming therapeutic problems. MSCs have multipotential characteristics such as the ability to differentiate into variety of cell types, easy access, immunomodulation, tissue repair, exertion of trophic factors, exosome secretion and efficient homing. In this review, we will discuss the characteristics of MSCs and their possible therapeutic mechanisms in ALS patients. © 2016 Bentham Science Publishers.
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