Recent Trends in Diagnostic Biomarkers of Tumor Microenvironment Publisher Pubmed



Siminzar P^{1, 2} ; Tohidkia MR¹ ; Eppard E³ ; Vahidfar N⁴ ; Tarighatnia A¹ ; Aghanejad A^{1, 2} Show Affiliations
Source: Molecular Imaging and Biology Published:2023

Abstract

The tumor microenvironment (TME) play critical roles in tumor survival, progression, and metastasis and can be considered potential targets for molecular imaging of cancer. The targeting agents for imaging of TME components (e.g., fibroblasts, mesenchymal stromal cells, immune cells, extracellular matrix, blood vessels) provide a promising strategy to target these biomarkers for the early diagnosis of cancers. Moreover, various cancer types have similar tumor immune microenvironment (TIME) features that targeting those biomarkers and offer clinically translatable molecular imaging of cancers. In this review, we categorize and summarize the components in TME which have been targeted for molecular imaging. Moreover, this review updated the recent progress in targeted imaging of TIME biological molecules by various modalities for the early detection of cancer. Graphical Abstract: [Figure not available: see fulltext.] © 2022, The Author(s), under exclusive licence to World Molecular Imaging Society.