The Role of Minocycline in Alleviating Aluminum Phosphide-Induced Cardiac Hemodynamic and Renal Toxicity

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The Role of Minocycline in Alleviating Aluminum Phosphide-Induced Cardiac Hemodynamic and Renal Toxicity Publisher Pubmed

Haghiaminjan H¹ ; Baeeri M² ; Rahimifard M² ; Alizadeh A³ ; Hodjat M^{2, 4} ; Hassani S² ; Asghari MH⁵ ; Abdollahi A⁶ ; Didari T² ; Hosseini R¹ ; Sharifzadeh M¹ ; Abdollahi M^{1, 2}

Source: Environmental Toxicology and Pharmacology Published:2018

Abstract

Poisoning with aluminum phosphide (AlP) has been attributed to the high rate of mortality among many Asian countries. It affects several organs, mainly heart and kidney. Numerous literature demonstrated the valuable effect of minocycline in mitigating pathological symptoms of heart and kidney disease. The aim of the present study was to evaluate the probable protective effect of minocycline on cardiac hemodynamic parameters abnormalities and renal toxicity induced by AlP-poisoning in the rat model. AlP was administered by gavage at 12 mg/kg body weight followed by injection of minocycline for two interval times of 12 and 24 h, at 40, 80, 120 mg/kg body weight. Electrocardiographic (ECG) parameters were monitored, 30 min after AlP gavage for 6 h using an electronic cardiovascular monitoring device. Kidney tissue and serum were collected for the study of histology, mitochondrial complexes I, II, IV, lactate dehydrogenase (LDH) and myeloperoxidase (MPO) activity, ADP/ATP ratio, mitochondrial cytochrome c release, apoptosis, lactate, BUN, and Cr levels. The results demonstrated that AlP induces ECG abnormalities, and failure of heart rate and blood pressure, which improved significantly by minocycline. Minocycline treatment significantly improved complexes I, IV, MPO and LDH activities, and also reduced the ADP/ATP ratio, lactate level, release of cytochrome c, and apoptosis in the kidney following AlP-poisoning. Also, the histological results showed an improvement of kidney injury in minocycline treated groups. In conclusion, the findings of this study showed that minocycline could improve cardiac hemodynamic abnormalities and kidney injury following AlP-poisoning, suggesting minocycline might be a possible candidate for the treatment of AlP-poisoning. © 2018 Elsevier B.V.

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Style	Citing Format
MLA	Haghiaminjan H, et al.. "The Role of Minocycline in Alleviating Aluminum Phosphide-Induced Cardiac Hemodynamic and Renal Toxicity." Environmental Toxicology and Pharmacology, vol. 64, no. , 2018, pp. 26-40.
APA	Haghiaminjan H, Baeeri M, Rahimifard M, Alizadeh A, Hodjat M, Hassani S, Asghari MH, Abdollahi A, Didari T, Hosseini R, Sharifzadeh M, Abdollahi M (2018). The Role of Minocycline in Alleviating Aluminum Phosphide-Induced Cardiac Hemodynamic and Renal Toxicity. Environmental Toxicology and Pharmacology, 64(), 26-40.
Chicago	Haghiaminjan H, Baeeri M, Rahimifard M, Alizadeh A, Hodjat M, Hassani S, Asghari MH, et al.. "The Role of Minocycline in Alleviating Aluminum Phosphide-Induced Cardiac Hemodynamic and Renal Toxicity." Environmental Toxicology and Pharmacology 64, no. (2018): 26-40.
Harvard	Haghiaminjan H et al. (2018) 'The Role of Minocycline in Alleviating Aluminum Phosphide-Induced Cardiac Hemodynamic and Renal Toxicity', Environmental Toxicology and Pharmacology, 64(), pp. 26-40.
Vancouver	Haghiaminjan H, Baeeri M, Rahimifard M, Alizadeh A, Hodjat M, Hassani S, et al.. The Role of Minocycline in Alleviating Aluminum Phosphide-Induced Cardiac Hemodynamic and Renal Toxicity. Environmental Toxicology and Pharmacology. 2018;64():26-40.
BibTex	@article{ author = {Haghiaminjan H and Baeeri M and Rahimifard M and Alizadeh A and Hodjat M and Hassani S and Asghari MH and Abdollahi A and Didari T and Hosseini R and Sharifzadeh M and Abdollahi M}, title = {The Role of Minocycline in Alleviating Aluminum Phosphide-Induced Cardiac Hemodynamic and Renal Toxicity}, journal = {Environmental Toxicology and Pharmacology}, volume = {64}, number = {}, pages = {26-40}, year = {2018} }
RIS	TY - JOUR AU - Haghiaminjan H AU - Baeeri M AU - Rahimifard M AU - Alizadeh A AU - Hodjat M AU - Hassani S AU - Asghari MH AU - Abdollahi A AU - Didari T AU - Hosseini R AU - Sharifzadeh M AU - Abdollahi M TI - The Role of Minocycline in Alleviating Aluminum Phosphide-Induced Cardiac Hemodynamic and Renal Toxicity JO - Environmental Toxicology and Pharmacology VL - 64 IS - SP - 26 EP - 40 PY - 2018 ER -

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