Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of a Combination of Foeniculum Vulgare, Melissa Officinalis Extract, and Nigella Saliva Powder on Healthy Menopausal Women With Sexual Dysfunction: A Randomized Clinical Trial Publisher



Afshar S1 ; Afshar F2 ; Rezazade A1 ; Ardakani ZS3 ; Azar ZJ4 ; Amin G5 ; Shariat M6 ; Haghollahi F7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
  3. 3. Semnan University of Medical Sciences, Semnan, Iran
  4. 4. Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  5. 5. Department of Pharmacognosy and Medicinal Plant Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Jundishapur Journal of Natural Pharmaceutical Products Published:2020


Abstract

Background: Menopause is a critical period with frequent sexual disorders. Objectives: The current study assessed the therapeutic effect of a combination of the aerial part of Melissa officinalis, fennel fruit extract, and Nigella sativa seed powder on the sexual dysfunction of postmenopausal women. Methods: This randomized clinical trial was performed on 48 menopausal women from April 2015 to October 2017. The participants included the menopausal women referring to the clinic of Gorgan health centers aged between 41 and 54 years with natural menopause (amenorrhea for at least 12 months) and discomfort in sexual activity. They were randomized into two treatment groups. Group 1 (n = 27) received 1000 mg capsules (Melissa officinalis, fennel extract, and Nigella sativa powder), and group 2 (n = 21) received a placebo (1000 mg starch capsules (in an eight-week course of treatment (one capsule per day for each group). The variables in the female sexual function index (FSFI) questionnaire were compared in the two groups before and after the intervention. Results: The results showed that the mean scores of sexual dysfunction in the domains of arousal, lubrication, orgasm, satisfaction, and pain were not significantly different between the two groups (P > 0.05). Conclusions: Despite many studies on the effectiveness of Melissa, Foenculum, and Nigella, this study showed that a combination of Foeniculum vulgare, Melissa officinalis extract, and Nigella sativa seed powder does not improve the sexual function of postmenopausal women with sexual dysfunction, and it might be the synergism effect of this combination. Copyright © 2020, Author(s).
Related Docs
View other Related Docs
1. The Effect of Jazar Supplement on Quality of Life and Sexual Function in Postmenopausal Women: A Double-Blind, Randomized, Placebo-Controlled Trial, Evidence-based Complementary and Alternative Medicine (2021)
2. Effect of Melissa Officinalis (Lemon Balm) on Sexual Dysfunction in Women: A Double- Blind, Randomized, Placebo-Controlled Study, Iranian Journal of Pharmaceutical Research (2018)
3. Crocus Sativus (Saffron) in the Treatment of Female Sexual Dysfunction: A Three-Center, Double-Blind, Randomized, and Placebo-Controlled Clinical Trial, Avicenna Journal of Phytomedicine (2022)
4. The Effect of Intra-Vaginal Oxytocin on Sexual Function in Breastfeeding Mothers: A Randomized Triple-Blind Placebo-Controlled Trial, BMC Pregnancy and Childbirth (2022)
5. The Effect of Sexual Health Education Program on Women Sexual Function in Iran, Journal of Research in Health Sciences (2015)
6. Women's Sexual Function During the Postpartum Period: A Systematic Review on Measurement Tools, Medicine (United States) (2024)
7. The Effect of Sexual Counseling Based on Ex‑Plissit Model on Improving the Sexual Function of Married Women With Systemic Lupus Erythematosus: A Randomized Controlled Trial, Sexuality and Disability (2023)
8. The Effect of Ear Acupressure on Sexual Functioning Among Lactating Women: A Randomized Sham Controlled Trial, European Journal of Integrative Medicine (2023)
Experts (# of related papers)
View all Related Experts
Zahra Behboodi Moghadam (5)
Elham Ebrahimi (2)
Other Related Docs
9. The Effect of Soft Oral Capsule of Rose Oil on Sexual Dysfunction in Women of Reproductive Age: A Randomised Clinical Trial, European Journal of Integrative Medicine (2021)
10. Investigation of Sexual Dysfunction and Depression Prevalence in Neuromyelitis Optica Spectrum Disorder, Neurological Sciences (2023)
11. The Association Couple Burnout and Sexual Function in Primiparous Women During One Year After Childbirth: A Cross-Sectional Study Using Structural Equation Model Analysis, Iranian Journal of Psychiatry and Behavioral Sciences (2025)
12. Effect of Foeniculum Vulgare Mill. (Fennel) on Menopausal Symptoms in Postmenopausal Women: A Randomized, Triple-Blind, Placebo-Controlled Trial, Menopause (2017)
13. Evaluation of the Effect of Carrot Seed (Daucus Carota) in Women of Fertile Age With Hypoactive Sexual Desire Disorder: A Randomized Double-Blind Clinical Trial, Complementary Therapies in Medicine (2020)
14. Effects of Sensate Focus Technique on Female Sexual Function After Vaginal Delivery; [Effets De La Technique Sensate Focus Sur La Fonction Sexuelle Des Femmes Apres Un Accouchement Par Voie Basse], Sexologies (2021)
15. The Impact of Higgs Radiofrequency on Pelvic Organ Prolapse and Sexual Function Among Women Suffering From Vaginal Laxity, Journal of Obstetrics# Gynecology and Cancer Research (2021)
16. Vitamin E and Ginseng Supplementation to Enhance Female Sexual Function: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial, Women and Health (2020)
17. Using Ecological Momentary Assessment to Investigate Short-Term Variations in Sexual Functioning in a Sample of Peri-Menopausal Women From Iran, PLoS ONE (2015)
18. The Effect of Sexual Education Based on the Sexual Health Model on Sexual Function Among Women Living in the Suburbs: Study Protocol for a Randomized Controlled Trial, Reproductive Health (2024)
19. Spinal Cord Injury and Women's Sexual Life: Case-Control Study, Spinal Cord (2017)
20. The Effect of Mindfulness-Based Cognitive-Behavioral Sex Therapy on Improving Sexual Desire Disorder, Sexual Distress, Sexual Self-Disclosure and Sexual Function in Women: A Randomized Controlled Clinical Trial, Journal of Sex and Marital Therapy (2022)
21. A Comprehensive Interventional Program Based on the Needs and Concerns Related to Female Genital Cosmetic Surgeries: Protocol for a Multistage Mixed Methods Study, Reproductive Health (2023)