Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
High Prevalence of Sars-Coronavirus-2 in Patients With Inflammatory Bowel Disease and the Role of Soluble Angiotensin Converting Enzyme2 Publisher



Shahrokh S1 ; Baradaran Ghavami S1 ; Asadzadeh Aghdaei H1 ; Parigi TL2, 3 ; Farmani M1 ; Danese S2, 4 ; Ebrahimi Daryani N5 ; Vossoughinia H6 ; Balaii H1 ; Alborzi F5 ; Khoramjoo SM1 ; Khanabadi B1 ; Seyed Salehi A1 ; Bastani A7 Show All Authors
Authors
  1. Shahrokh S1
  2. Baradaran Ghavami S1
  3. Asadzadeh Aghdaei H1
  4. Parigi TL2, 3
  5. Farmani M1
  6. Danese S2, 4
  7. Ebrahimi Daryani N5
  8. Vossoughinia H6
  9. Balaii H1
  10. Alborzi F5
  11. Khoramjoo SM1
  12. Khanabadi B1
  13. Seyed Salehi A1
  14. Bastani A7
  15. Sharifi M8
  16. Safari MT1
  17. Malekpour H1
  18. Sherkat G9
  19. Saberafsharian M10
  20. Miri MB11
  21. Moosavi SH11
  22. Anaraki F12
  23. Nazemalhosseinimojarad E1
  24. Mohebi SR1
  25. Shojaie S1
  26. Pourhoseingholi MA1
  27. Zali MR1

Source: Archives of Physiology and Biochemistry Published:2022


Abstract

Context: Patients with inflammatory bowel disease (IBD) were found to have the higher intestinal expression of Angiotensin-Converting Enzyme2 (ACE2) that could consequently increase susceptibility to COVID-19 infection. Objective: This study reports the outcomes of COVID-19 infection in a large cohort of IBD patients. We compare levels of serum ACE and IFN-α between COVID19 patients with and without IBD. We performed a cross-sectional retrospective multicenter study. Methods: We enrolled patients with IBD screened for SARS-COV-2 in six medical centres in Iran from June to November 2020. The blood samples were drawn to measure COVID-19 IgM and IgG, and serum levels of sACE2, sACE1, and interferon-α, regardless of suspicious symptoms have done the molecular test. Results: A total of 534 IBD patients were included in the study. Of these, 109 (20.0%) cases had detectable IgG and IgM against SARS-CoV-2. sACE2 levels were higher in IBD patients than controls, whereas ACE1and IFN-α levels were similar among groups. © 2022 Informa UK Limited, trading as Taylor & Francis Group.
Other Related Docs
7. Case Fatality Rate of Covid-19: A Systematic Review and Meta-Analysis, Journal of Preventive Medicine and Hygiene (2021)
11. Covid-19: A Trigger of Autoimmune Diseases, Cell Biology International (2023)
12. Soluble Ace2 As a Risk or Prognostic Factor in Covid-19 Patients: A Cross-Sectional Study, Medical Journal of the Islamic Republic of Iran (2022)
15. Pathologic Features of Covid-19: A Concise Review, Pathology Research and Practice (2020)