Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19

Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19 Publisher Pubmed

Abolhassani H^{1, 3} ; Delavari S³ ; Landegren N^{2, 6} ; Shokri S⁷ ; Bastard P^{8, 9, 10} ; Du L¹ ; Zuo F¹ ; Hajebi R⁴ ; Abolnezhadian F¹¹ ; Iranparast S¹² ; Modaresi M⁵ ; Vosughimotlagh A¹³ ; Salami F³ ; Arandaguillen M² Show All Authors

Abolhassani H^{1, 3}
Delavari S³
Landegren N^{2, 6}
Shokri S⁷
Bastard P^{8, 9, 10}
Du L¹
Zuo F¹
Hajebi R⁴
Abolnezhadian F¹¹
Iranparast S¹²
Modaresi M⁵
Vosughimotlagh A¹³
Salami F³
Arandaguillen M²
Cobat A^{9, 10}
Marcotte H¹
Zhang SY^{8, 9, 10}
Zhang Q^{8, 9}
Rezaei N³
Casanova JL^{8, 9, 10, 14}
Kampe O^{2, 15}
Hammarstrom L¹
Panhammarstrom Q¹

Show Affiliations

1. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Stockholm, Sweden
2. Centre for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden
3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of General Surgery, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
5. Division of Pediatrics Pulmonary Disease, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
7. Department of Pediatrics, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran
8. St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY
9. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale U1163, Necker Hospital for Sick Children, Paris, France
10. University of Paris, Imagine Institute, Paris, France
11. Department of Pediatrics, Abuzar Children's Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
12. Department of Immunology, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
13. Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran
14. Howard Hughes Medical Institute, New York, NY
15. Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden

Source: Journal of Allergy and Clinical Immunology Published:2022

Abstract

Background: Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals are asymptomatic or only exhibit mild disease. In about 10% of cases, the infection leads to hypoxemic pneumonia, although it is much more rare in children. Objective: We evaluated 31 young patients aged 0.5 to 19 years who had preexisting inborn errors of immunity (IEI) but lacked a molecular diagnosis and were later diagnosed with coronavirus disease 2019 (COVID-19) complications. Methods: Genetic evaluation by whole-exome sequencing was performed in all patients. SARS-CoV-2–specific antibodies, autoantibodies against type I IFN (IFN-I), and inflammatory factors in plasma were measured. We also reviewed COVID-19 disease severity/outcome in reported IEI patients. Results: A potential genetic cause of the IEI was identified in 28 patients (90.3%), including mutations that may affect IFN signaling, T- and B-cell function, the inflammasome, and the complement system. From tested patients 65.5% had detectable virus-specific antibodies, and 6.8% had autoantibodies neutralizing IFN-I. Five patients (16.1%) fulfilled the diagnostic criteria of multisystem inflammatory syndrome in children. Eleven patients (35.4%) died of COVID-19 complications. All together, at least 381 IEI children with COVID-19 have been reported in the literature to date. Although many patients with asymptomatic or mild disease may not have been reported, severe presentation of COVID-19 was observed in 23.6% of the published cases, and the mortality rate was 8.7%. Conclusions: Young patients with preexisting IEI may have higher mortality than children without IEI when infected with SARS-CoV-2. Elucidating the genetic basis of IEI patients with severe/critical COVID-19 may help to develop better strategies for prevention and treatment of severe COVID-19 disease and complications in pediatric patients. © 2022 The Authors

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Style	Citing Format
MLA	Abolhassani H, et al.. "Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19." Journal of Allergy and Clinical Immunology, vol. 150, no. 5, 2022, pp. 1059-1073.
APA	Abolhassani H, Delavari S, Landegren N, Shokri S, Bastard P, Du L, Zuo F, Hajebi R, Abolnezhadian F, Iranparast S, Modaresi M, Vosughimotlagh A, Salami F, Arandaguillen M, Cobat A, Marcotte H, Zhang SY, Zhang Q, Rezaei N, ... Panhammarstrom Q (2022). Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19. Journal of Allergy and Clinical Immunology, 150(5), 1059-1073.
Chicago	Abolhassani H, Delavari S, Landegren N, Shokri S, Bastard P, Du L, Zuo F, et al.. "Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19." Journal of Allergy and Clinical Immunology 150, no. 5 (2022): 1059-1073.
Harvard	Abolhassani H et al. (2022) 'Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19', Journal of Allergy and Clinical Immunology, 150(5), pp. 1059-1073.
Vancouver	Abolhassani H, Delavari S, Landegren N, Shokri S, Bastard P, Du L, et al.. Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19. Journal of Allergy and Clinical Immunology. 2022;150(5):1059-1073.
BibTex	@article{ author = {Abolhassani H and Delavari S and Landegren N and Shokri S and Bastard P and Du L and Zuo F and Hajebi R and Abolnezhadian F and Iranparast S and Modaresi M and Vosughimotlagh A and Salami F and Arandaguillen M and Cobat A and Marcotte H and Zhang SY and Zhang Q and Rezaei N and Casanova JL and Kampe O and Hammarstrom L and Panhammarstrom Q}, title = {Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19}, journal = {Journal of Allergy and Clinical Immunology}, volume = {150}, number = {5}, pages = {1059-1073}, year = {2022} }
RIS	TY - JOUR AU - Abolhassani H AU - Delavari S AU - Landegren N AU - Shokri S AU - Bastard P AU - Du L AU - Zuo F AU - Hajebi R AU - Abolnezhadian F AU - Iranparast S AU - Modaresi M AU - Vosughimotlagh A AU - Salami F AU - Arandaguillen M AU - Cobat A AU - Marcotte H AU - Zhang SY AU - Zhang Q AU - Rezaei N AU - Casanova JL AU - Kampe O AU - Hammarstrom L AU - Panhammarstrom Q TI - Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19 JO - Journal of Allergy and Clinical Immunology VL - 150 IS - 5 SP - 1059 EP - 1073 PY - 2022 ER -

Style

Citing Format

MLA

Abolhassani H, et al.. "Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19." Journal of Allergy and Clinical Immunology, vol. 150, no. 5, 2022, pp. 1059-1073.

APA

Abolhassani H, Delavari S, Landegren N, Shokri S, Bastard P, Du L, Zuo F, Hajebi R, Abolnezhadian F, Iranparast S, Modaresi M, Vosughimotlagh A, Salami F, Arandaguillen M, Cobat A, Marcotte H, Zhang SY, Zhang Q, Rezaei N, ... Panhammarstrom Q (2022). Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19. Journal of Allergy and Clinical Immunology, 150(5), 1059-1073.

Chicago

Abolhassani H, Delavari S, Landegren N, Shokri S, Bastard P, Du L, Zuo F, et al.. "Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19." Journal of Allergy and Clinical Immunology 150, no. 5 (2022): 1059-1073.

Harvard

Abolhassani H et al. (2022) 'Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19', Journal of Allergy and Clinical Immunology, 150(5), pp. 1059-1073.

Vancouver

Abolhassani H, Delavari S, Landegren N, Shokri S, Bastard P, Du L, et al.. Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19. Journal of Allergy and Clinical Immunology. 2022;150(5):1059-1073.

BibTex

@article{ author = {Abolhassani H and Delavari S and Landegren N and Shokri S and Bastard P and Du L and Zuo F and Hajebi R and Abolnezhadian F and Iranparast S and Modaresi M and Vosughimotlagh A and Salami F and Arandaguillen M and Cobat A and Marcotte H and Zhang SY and Zhang Q and Rezaei N and Casanova JL and Kampe O and Hammarstrom L and Panhammarstrom Q}, title = {Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19}, journal = {Journal of Allergy and Clinical Immunology}, volume = {150}, number = {5}, pages = {1059-1073}, year = {2022} }

RIS

TY - JOUR
AU - Abolhassani H
AU - Delavari S
AU - Landegren N
AU - Shokri S
AU - Bastard P
AU - Du L
AU - Zuo F
AU - Hajebi R
AU - Abolnezhadian F
AU - Iranparast S
AU - Modaresi M
AU - Vosughimotlagh A
AU - Salami F
AU - Arandaguillen M
AU - Cobat A
AU - Marcotte H
AU - Zhang SY
AU - Zhang Q
AU - Rezaei N
AU - Casanova JL
AU - Kampe O
AU - Hammarstrom L
AU - Panhammarstrom Q
TI - Genetic and Immunologic Evaluation of Children With Inborn Errors of Immunity and Severe or Critical Covid-19
JO - Journal of Allergy and Clinical Immunology
VL - 150
IS - 5
SP - 1059
EP - 1073
PY - 2022
ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract