A Review of Chitosan Role in Milk Bioactive-Based Drug Delivery, Smart Packaging and Biosensors: Recent Advances and Developments Publisher Pubmed



Hasannezhad H^{1, 2} ; Bakhshi A^{1, 3} ; Mozafari MR⁴ ; Naghib SM³
Source: International Journal of Biological Macromolecules Published:2025

Abstract

Chitosan, a versatile biopolymer derived from chitin, is increasingly recognized in the milk industry for its multifunctional applications in drug delivery, smart packaging, and biosensor development. This review provides a comprehensive analysis of recent advances in chitosan production techniques. These include chemical, biological, and novel methods such as deep eutectic solvents (DES), microwave-assisted approaches, and laser-assisted processes. Surface modification strategies to enhance its functional properties are also discussed. The review highlights the development of various chitosan-based nanocarriers, including nanoparticles, nanofibers, nanogels, and nanocomposites. It emphasizes their stability when combined with milk bioactive ingredients like lipids, peptides, lactose, and minerals. The gastrointestinal fate and safety of chitosan nanoparticles are critically evaluated, showcasing their potential for safe consumption in dairy-related applications. In drug delivery systems, chitosan exhibits excellent compatibility with milk-derived carbohydrates, proteins, and minerals, enabling the development of innovative drug delivery platforms. Additionally, its incorporation into smart packaging materials enhances the shelf-life and quality of dairy products. Chitosan-based biosensors offer precise contaminant detection in the milk industry by enabling precise detection of contaminants such as Bisphenol A, melamine, bacteria, drugs, antibiotics, toxins, heavy metals, and allergens, thus ensuring food safety and quality. Emerging trends, including the integration of artificial intelligence, advanced gene editing, and multifunctional chitosan, are discussed, offering insights into future personalized delivery systems and merging food and drug technologies. The review concludes by highlighting gaps in current research and offering recommendations for future exploration. These suggestions aim to optimize chitosan's unique properties to address key challenges in the milk industry. This article serves as a valuable resource for researchers, industry professionals, and policymakers aiming to innovate within the dairy sector using chitosan-based technologies. © 2024 Elsevier B.V.