Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Chitosan Crosslinkers and Their Functionality in 3D Bioprinting to Produce Chitosan-Based Bioinks Publisher



Afra S1 ; Samadi A2 ; Asadi P3 ; Bordbar M4 ; Iloukhani M5 ; Rai A6 ; Aghajanpour M7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
  2. 2. Department of Basic Sciences, School of Medicine, Bam University of Medical Sciences, Bam, Iran
  3. 3. Nano-drug Delivery Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Department of Biotechnology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
  5. 5. Biomedical Engineering Department, Amiralam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  6. 6. Department of Histopathology, Post Graduate Institute of Medical Education & Research, Chandigarh, 160012, India
  7. 7. Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Tehran, Iran

Source: Inorganic Chemistry Communications Published:2024


Abstract

Chitosan is a nontoxic natural material at a reasonable price. These two essential properties of chitosan make it attractive in research and industries related to tissue engineering and 3D bioprinting. Chitosan, as a formable hydrogel, has various crosslinkers affect the toxicity and printability of the chitosan-based hydrogels. Crosslinkers of biomaterials play a significant role in their applications in tissue engineering. Crosslinkers can determine the final cytotoxicity of hydrogel-based scaffolds. This review investigates significant chitosan crosslinkers, including β-glycerophosphate, tripolyphosphate, aldehydes, genipin, and the effects of different pH. This study concentrates on chitosan as a favorite biomaterial and surveys its major crosslinkers for suitability in bioinks. © 2024 Elsevier B.V.
Related Docs
View other Related Docs
1. Innovating Chitosan-Based Bioinks for Dermal Wound Healing: Current Progress and Future Prospects, International Journal of Biological Macromolecules (2025)
2. Chitosan/Hydroxyapatite Hydrogels for Localized Drug Delivery and Tissue Engineering: A Review, Carbohydrate Polymer Technologies and Applications (2025)
3. Injectable Natural Polymer Compound for Tissue Engineering of Intervertebral Disc: In Vitro Study, Materials Science and Engineering C (2017)
4. Fabrication Technology of Chitosan-Based Ipn: Drug Delivery Application, Interpenetrating Polymer Network: Biomedical Applications (2020)
5. Hydrogels and Biohydrogels: Investigation of Origin of Production, Production Methods, and Application, Polymer Bulletin (2023)
6. The Recent Advancement in the Chitosan-Based Thermosensitive Hydrogel for Tissue Regeneration, Journal of Drug Delivery Science and Technology (2023)
7. 3D Printing of Bioactive Materials for Drug Delivery Applications, Expert Opinion on Drug Delivery (2022)
8. Derivation of Epithelial-Like Cells From Eyelid Fat-Derived Stem Cells in Thermosensitive Hydrogel, Journal of Biomaterials Science# Polymer Edition (2016)
Experts (# of related papers)
View all Related Experts
Mohammad Akrami (1)
Mona Navaei-Nigjeh (1)
Other Related Docs
9. Naturally Occurring Biological Macromolecules-Based Hydrogels: Potential Biomaterials for Peripheral Nerve Regeneration, International Journal of Biological Macromolecules (2020)
10. Incorporation of Montmorillonite Into Microfluidics-Generated Chitosan Microfibers Enhances Neuron-Like Pc12 Cells for Application in Neural Tissue Engineering, Carbohydrate Polymers (2024)
11. Three Dimensional Spongy Fibroin Scaffolds Containing Keratin/Vanillin Particles As an Antibacterial Skin Tissue Engineering Scaffold, International Journal of Polymeric Materials and Polymeric Biomaterials (2022)