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Review: The Latest Advances in Biomedical Applications of Chitosan Hydrogel As a Powerful Natural Structure With Eye-Catching Biological Properties Publisher



Eivazzadehkeihan R1 ; Noruzi EB2 ; Mehrban SF3 ; Aliabadi HAM4, 5 ; Karimi M6 ; Mohammadi A1 ; Maleki A1 ; Mahdavi M7 ; Larijani B7 ; Shalan AE8, 9
Authors
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Authors Affiliations
  1. 1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Department of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
  3. 3. Non-Metallic Materials Research Group, Niroo Research Institute, P.O. Box 14665517, Tehran, Iran
  4. 4. Faculty of Chemistry, K.N. Toosi University of Technology, Tehran, Iran
  5. 5. Protein Chemistry Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  6. 6. Chemistry Department, Tarbiat Modares University, Tehran, Iran
  7. 7. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. BCMaterials, Basque Center for Materials, Applications and Nanostructures, Martina Casiano, UPV/EHU Science Park, Barrio Sarriena S/N, Leioa, 48940, Spain
  9. 9. Central Metallurgical Research and Development Institute (CMRDI), P. O. Box 87, Helwan, Cairo, 11421, Egypt

Source: Journal of Materials Science Published:2022


Abstract

Chitosan is one of the natural cationic polymers with unique properties such as non-toxicity, biodegradability, biocompatibility, environmentally friendly that has various biomedical applications. Chitosan-based hydrogels are hydrophilic polymer biomaterials with a three-dimensional cross-linked network structure. The methods of chitosan hydrogels fabricating are categorized into chemically and physically cross-linking between polymer chains. These hydrogels are employed for clinical applications because of their biological and physicochemical features. The most important applications of chitosan hydrogels have been considered in this review. Chitosan hydrogels are applicable in drug delivery due to their ability to control releasing of drugs through pH-responsive and temperature-responsive release approaches and the network structure that can carry drugs. Also, chitosan hydrogels are an excellent choice for wound healing because of their features such as antibacterial, providing moisture and heat in the wound area, biocompatibility, and so forth. Furthermore, swelling capacity, porosity, and mechanical properties make these hydrogels a good candidate as a scaffold for tissue formation. The other applications of chitosan hydrogels in biosensors, protein purification, and dye materials separation from wastewater have been considered in this review. Graphical abstract: [Figure not available: see fulltext.]. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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